基于硬脂酸改性纳米碳酸钙的雷公藤红素缓释固体分散体的研究  

Sustained Release Solid Dispersion of Tripterine Carried by Modified Nano-CaCO_3

作　　者：陈小云[1,2] 张振海[1] 胡绍英[1,2] 唐静[2] 黄赛燕[2] 贾晓斌[1,2] 

机构地区：[1]江苏省中医药研究院,国家中医药管理局中药释药系统重点研究室,南京210028 [2]南京中医药大学,南京210046

出　　处：《中国药学杂志》2013年第16期1380-1384,共5页Chinese Pharmaceutical Journal

基　　金：江苏省高等学校大学生创新训练计划项目(011042004000);江苏省中医药领军人才专项(2006)

摘　　要：目的利用硬脂酸对纳米CaCO3进行表面改性,制备疏水性纳米CaCO3,并以该材料为载体,制备雷公藤红素缓释固体分散体。方法用溶剂法制备缓释固体分散体,用扫描电镜分析、透射电镜分析、差示量热扫描分析、X-射线粉末衍射法、红外光谱分析等表征手段对改性纳米CaCO3及固体分散体的结构特征进行分析研究,考察其体外释药性能。结果药物与改性纳米CaCO3比例为1∶4时所制备的固体分散体中雷公藤红素以非晶型分散于载体表面,0.5 h体外释放度为7.05%,12 h的释放度达90.03%,缓释效果良好。结论经硬脂酸改性后的纳米CaCO3可以作为雷公藤红素的缓释固体分散体的载体。OBJECTIVE To prepare hydrophobic nano-CaCO3 by nano-CaCO3 and stearic acid. And to prepare tripterine solid dispersion using the new material as a carrier by solvent method. METHODS The structure of modified nano-CaCO3 was characterized by TEM, DSC, XRD and FTIR. Meanwhile the solid dispersions were characterized by SEM, DSC, XRD and FTIR, and the in vitro dissolution test of tripterine was performed. RESULTS When the ratio of drug to modified nano-CaCO3 was 1 ： 4, tripterine could be dispersed amorphously in the carrier. And the accumulative drug-release percentage in vitro at 0. 5 h was 7.05%. With the time in- creasing, the accumulative drug-release percentage also increased to 90. 03% at 12 h. Moreover, tripterine solid dispersion had a better sustained release effect. CONCLUSION The nano-CaCO3 modified by stearic acid can be used as controlled-release carrier for tripterine.

关 键 词：硬脂酸 改性纳米CACO3 雷公藤红素 缓释 固体分散体 

分 类 号：R944[医药卫生—药剂学]