海洛因成瘾者前额叶内侧皮质的静息状态功能连接  

Resting-state Functional Connectivity of Medial Prefrontal Cortex in the Active Opiates User

作　　者：刘海洪[1] 阎媛[2] 张会然[3] 郝以辉[4] 刘哲宁[3] 

机构地区：[1]中南大学湘雅医院心理卫生中心,长沙410008 [2]广东工业大学心理健康教育与咨询中心,广州510006 [3]中南大学湘雅二医院精神卫生研究所,长沙410011 [4]郑州大学第一附属医院精神医学科

出　　处：《中国临床心理学杂志》2013年第4期538-540,共3页Chinese Journal of Clinical Psychology

基　　金：国家自然科学基金青年科学基金项目(81000587);高等学校博士学科点专项科研基金项目(20100162120048)

摘　　要：目的:探讨海洛因成瘾者脑默认网络静息状态功能连接的异常。方法:对正在接受美沙酮维持治疗的15例海洛因依赖者和15例健康对照进行静息状态脑功能磁共振扫描,以独立成分分析法获取每一个体的默认网络,并比较两组默认网络的功能连接差异。结果:与健康对照相比,海洛因成瘾者双侧前额叶内侧皮质、左侧颞中回和颞下回、小脑的功能连接升高。结论:前额叶内侧皮质可能是物质成瘾的关键脑区,可为成瘾的生物学诊断和靶向治疗提供线索。Objective： To investigate the effects of active opiates use on the resting-state functional connectivity of the default network. Methods： Resting-state functional images were obtained from 15 heroin-dependent subjects on methadone maintenance therapy and 15 healthy controls matched for sex, age and education years. Individual＇s default network was obtained by independent component analysis, and the default network difference between the two groups was explored by two sample t test. Results： Compared with the healthy controls, active opiates user showed increased resting- state functional connectivity in bilateral medial prefrontal cortex （MPFC）, left middle and inferior temporal gyms and cere- bellum. Conclusion： The MPFC may be a crucial area of substance addiction. This findings provides cues for the biologi- cal diagnosis and region-targeted therapy of addiction.

关 键 词：前额叶内侧皮质 默认网络 功能连接 成瘾 

分 类 号：R395.1[哲学宗教—心理学]