生物素衍生物自组装膜制备及其覆盖度的电化学测定  

Preparation of biotin derivatives self-assembled monolayer and its coverage of the electrochemical determination

作　　者：徐常龙[1] 曹小华[1] 陶春元[1] 柳闽生[2] 张爱东[3] 

机构地区：[1]九江学院生命科学学院,江西九江332000 [2]南京晓庄学院化学系,江苏南京210017 [3]华中师范大学化学学院,湖北武汉430079

出　　处：《化学研究与应用》2013年第8期1085-1090,共6页Chemical Research and Application

基　　金：国家自然科学基金项目(21161009)资助;江西省自然科学基金项目(20114BAB213002;20132BAB203004)资助;江西省教育厅科技项目(GJJ10626)资助;九江学院质量工程项目(11XSCXXSY4)资助

摘　　要：利用循环伏安法和电化学交流阻抗谱研究了MBDA/Au,MBTA/Au,TBDA/Au,TBTA/Au修饰电极以及MBDA与DT混合自组装/Au、TBTA与DT混合自组装/Au修饰电极的覆盖度。结果表明这些自组装膜在金电极表面的覆盖度均比较高,达到99%以上;对同一类修饰电极,混合自组装膜的覆盖度高于单组分自组装膜的覆盖度,混合自组装体系的覆盖度随着DT比例的增加而增加;同类物质,长链化合物在金表面的覆盖度大于短链化合物,含二硫键的化合物与金电极的键合能力比含一个巯基的化合物键合能力强。The electrochemical cyclic voltammetry and electrochemical impendence spectra were employed to characterize the coverage of the pure SAMs of MBDA/Au,MBTA/Au,TBDA/Au and TBTA/Au.Meanwhile,using 11.11′-diundecanolthiol（DT）as the medium molecule,the mixed SAMs of MBDA/DT and TBTA/DT on gold were also fabricated.The results showed that closely packed and well ordered SAMs had been fabricated and their surface coverages were over 99%.Mixed SAMs had higher coverages than the corresponding pure SAMs,and the coverage increases with the increase of the molar ratio of the medium molecule DT.At the same time,with the lengthening of the ether linkage between thioctic acid or 11-mercaptoundecanoic acid and biotin,the SAMs would have a greater surface coverage.

关 键 词：自组装膜 生物素衍生物 循环伏安法 电化学交流阻抗谱 

分 类 号：O657[理学—分析化学]