静注声学造影剂FX530对比观察肝脏、肾脏和睾丸血流灌注的实验研究  

Contrast Study of Liver,Kidney and Testis Perfusion in Rabbits by Intravenous Injection of FX530

作　　者：柳建华[1] 张青萍[2] 周翔[2] 周玉清[2] 黄道中[2] 乐桂蓉[2] 黎春蕾[2] 

机构地区：[1]广州市第一人民医院功能科,510180 [2]武汉同济医科大学附属同济医院超声科,430030

出　　处：《中国超声医学杂志》2000年第11期805-808,共4页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 :由于生物体内的肝脏、肾脏和睾丸具有不同的血管分布特征 ,本研究旨在评价经静脉注射新型声学造影剂 FX5 30后超声对比观察这些实质脏器的血流灌注情况。方法 :造影前观察正常大耳白兔肝脏、肾脏和睾丸二维灰阶及彩色多普勒图像 ;经静脉注射 FX5 30后观察各脏器实质和血管增强出现的时间与部位、持续时间、增强消退时间 ,并对造影前后二维灰阶图像进行视频密度分析。结果 :造影后 ,肝脏二维灰阶增强分为四个连续的时相即动脉相、门静脉相、毛细血管相和延迟血管相 ,实质增强有“滞留增强”现象 ;肾脏二维灰阶增强分为动脉相、毛细血管相和延迟血管相 ,肾实质增强表现为一过性 ;睾丸仅表现为血管增强 ,睾丸实质无增强。三个脏器彩色多普勒血流增强均可分为动脉相、毛细血管相和延迟血管相。结论 :应用新型声学造影剂可良好地观察具有不同血管分布的肝脏、肾脏和睾丸实质的血流灌注情况。Objective:Because of different distributions of blood vessels in liver,kidney and testis,perfusion of the organs was evaluated by ultrasound after intravenous administration of a new generation of ultrasonographic contrast agent,FX 530.Methods:Grey scale ultrasonography,color Doppler flow imaging and color Doppler energy imaging were used to visualize the pictures of liver,kidney and testis.After intravenous administration of FX530,appearance,duration and fadeaway of enhancement in the organs were recorded.The grey scale intensity of the organ parenchyma was quantified before and after injection.Paired t test was used to compare the intensity value.Results:After having injected FX530,enhancement of liver on grey scale imaging was divided into four continuous phases arterial,phase,portal veinous phase,capillary phase and delayed vascular phase,three phases in kidney—arterial,capillary and delayed vascular phases,but no parenchyma enhancement appeared in testis.Parenchyma enhancement in liver showed“detained enhancement”,while in kidney it showed “wash in and wash out”.Enhancement of flow signals in each organ on color flow imaging was divided into three phases arterial ,capillary and delayed vascular phases.Conclusions:Perfusion of liver,kidney and testis each of which has different distribution of blood vessels could be indentified by using intravenous injection of FX 530.

关 键 词：声学造影剂 静脉灌注 FX530 肝脏 肾脏 睾丸 

分 类 号：R445.1[医药卫生—影像医学与核医学] R981[医药卫生—诊断学]