不同刺激量脑活素穴位注射对小鼠衰老模型空间分辨学习能力的影响  

Effect of Point Injection of Brain Hormone on Spatial Distinction Learning Ability of Mice Aging Model

作　　者：王中林[1] 焦瑞清[2] 徐恒泽[1] 

机构地区：[1]南京中医药大学第二临床医学院,江苏南京210029 [2]南京大学生物化学系医药生物技术国家重点实验室,江苏南京210008

出　　处：《南京中医药大学学报》2000年第6期358-360,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省教委自然科学基金资助!(95068)

摘　　要：目的观察相同剂量脑活素以不同刺激量穴位注射百会、大椎穴，对Ｄ－半乳糖所致衰老模型小鼠的学习能力的影响。方法三因素三水平正交设计，以Ｙ迷宫空间分辨学习行为为指标。结果在药物浓度、治疗间隔、治疗时相３个因素中，治疗间隔是主要因素，治疗时相和药物浓度则影响不大。结论对促进Ｄ－半乳糖所致小鼠衰老模型学习能力作用最强的脑活素穴位注射治疗方案是原药稀释３０倍，每日 １次，午间治疗。OBFECTIVE To observe the effect of injection of the same dosage of brain hormone into the acupuncture points "Baihui" and "Dazhui" with different amount stimulation on the learning ability of mice aging model made by using D-galactose. METHOD The three-fac- factor three-level orthogonal design was employed with the y-labyrinth spatial distinction learning ability as die index. RESULT Amoong the three factors of medicine concentration, interval of treatment and time phase of treatment, the interval of treatment is the main factor, and the other two factors have little to do with the effect of treatment. The optimal method for point injection of brain hormone in promoting the learning ability of mice aging model is to use 30-time diluent of the original medicine for point injection once daily at noon.

关 键 词：衰老 脑活素 D-半乳糖 穴位注射 

分 类 号：R971[医药卫生—药品] R339.38[医药卫生—药学]