食欲素水平与慢性阻塞性肺疾病发生营养不足的相关性  

Correlation between orexin level and malnutrition in patients with chronic obstructive pulmonary disease

作　　者：陈文宇[1] 吕晓东[1] 刘加良[1] 杨琪[1] 张影清[1] 唐婷玉[2] 赵恬[2] 钦光跃[2] 

机构地区：[1]嘉兴市第一医院(嘉兴学院附属第一医院)呼吸科,浙江嘉兴314001 [2]浙江医院呼吸科,浙江杭州310013

出　　处：《中华临床营养杂志》2013年第4期199-203,共5页Chinese Journal of Clinical Nutrition

基　　金：浙江省中医药科学研究基金计划（2012ZA009）

摘　　要：目的 探讨血浆食欲素水平变化对慢性阻塞性肺疾病（COPD）发生营养不足的影响。方法 检测40例稳定期COPD患者（分为COPD伴营养不足组20例、COPD不伴营养不足组20例）及20例健康体检者的血浆食欲素、瘦素、肿瘤坏死因子-α及与营养状况相关的人体重指数。食欲素、瘦素和肿瘤坏死因子-α采用酶联免疫吸附法测定。分析食欲素与瘦素、肿瘤坏死因子-α及人体重指数之间的相关性。结果 COPD伴营养不足组血浆食欲素浓度为（0.11±0.01）μg/L，显著低于COPD不伴营养不足组（0.16±0.02）μg/L（P=0.000）和健康对照组（0.15±0.02）μg/L（P=0.002）。40例稳定期COPD患者血浆食欲素水平（0.14±0.03）μg/L与瘦素水平（16.05±3.56）ng/L、肿瘤坏死因子-α水平（9.18±2.70）ng/L存在负相关（r值分别为-0.295、-0.477，P值分别为0.049、0.002），与体重指数（20.88±4.20）kg/m2呈正相关（r=0.641，P=0.000）。结论 食欲素水平的变化与营养状况密切相关，但其具体机制尚需进一步研究。Objective To explore the influence of the change of plasma orexin level on undernutrition in patients with chronic obstructive pulmonary disease （COPD） at stable stage.Methods The plasma cytokines including orexin,leptin, and tumor necrosis factor-alpha （TNF-α） and human nutrition parameter [body mass index（BMI）] of 40 patients with COPD at stable stage and 20 healthy people were measured.The correlation of orexin with leptin, TNF-α, and BMI were analyzed.Results The plasma orexin level in undernutrition patients with COPD at stable stage [（0.11±0.01）μg/L] was significantly lower than non-undernutrition patients with COPD at stable stage [（0.16±0.02）μg/L] （P=0.000） and healthy people[（0.15±0.02）μg/L] （P=0.002）. The plasma orexin levels in 40 patients from COPD at stable stage [（0.14±0.03）μg/L] was negatively correlated with the plasma leptin [（16.05±3.56）ng/L] and TNF-α levels [（9.18±2.70）ng/L]（r=-0.295 and -0.477, P=0.049 and 0.002, respectively）. The plasma orexin level in 40 patients from COPD at stable stage was positively correlated with BMI [（20.88±4.20）kg/m2]（r=0.641, P=0.000）. Conclusion Plasma orexin level is closely correlated with nutrition status.

关 键 词：稳定期慢性阻塞性肺疾病 食欲素 营养不足 

分 类 号：R563.9[医药卫生—呼吸系统]