滇池微囊藻毒素对小鼠肝脏的毒性研究  

On Toxicity of Microcystin in Water of Dianchi Lake on Mice Liver

作　　者：杨黎江[1] 沈放[1] 仝向荣[1] 路斌[1] 付再伟[1] 邱金花[1] 

机构地区：[1]昆明学院生命科学与技术系,云南昆明650214

出　　处：《昆明学院学报》2013年第3期45-47,共3页Journal of Kunming University

基　　金：昆明学院科学研究资助项目(XJL12023)

摘　　要：为了解滇池微囊藻毒素对小鼠肝脏的损伤作用,提取滇池水华水样中微囊藻毒素对小鼠进行连续灌胃试验,之后取肝组织石蜡包埋、HE染色,观察小鼠肝脏组织显微结构.结果显示:小鼠肝脏充血、肿胀;微囊藻毒素使小鼠肝脏组织的显微结构出现异常变化,肝细胞索结构破坏,肝血窦明显扩张,部分肝细胞胞质溶解、核消失,病灶内有大量炎症细胞浸润.表明微囊藻毒素具有肝毒性,可破坏肝小叶的完整性,抑制肝脏的合成与解毒功能.To study whether Microcystin in Dianehi Lake injury liver of mice, mice were intragastrically administered by Microcystin extracted from Dianchi Lake Water-Blooms samples. Paraffin sections of liver were stained by HE staining and observed under micro- scope. The result displayed that livers of mice were congested and swelled after intragastrically administered Microcystin; mictrostruc- ture of liver became abnormal; hepatic cell cords were destroyed; hepatic sinusoid expanded obviously; cytoplasm of some liver cells dissolved; nuclear disappeared, and severe inflammatory cells infiltration were found in lesion area. In conclusion, Microcystin has hepatotoxic effects that destroy hepatic lobule structure to inhibit synthesis and detoxify of liver

关 键 词：微囊藻毒素 小鼠肝脏 毒性作用 HE染色 

分 类 号：R994.6[医药卫生—毒理学]