液体物料冷冻干燥的热点问题  

Hotspots in Freeze Drying of Aqueous Solutions

作　　者：赵延强[1,2] 于凯[1,2] 王维[2] 潘艳秋[1] 

机构地区：[1]大连理工大学化工学院,辽宁大连116024 [2]大连民族学院生命科学学院,辽宁大连116600

出　　处：《干燥技术与设备》2013年第4期11-17,共7页

摘　　要：液体物料冷冻干燥广泛应用于制药工业。其过程工艺的重要性正赢得世界范围的研究关注。文献已证实科学方法能够用最少的试差来提高产品质量。过程工艺的建立和规划需要系统地理解冷冻、冷冻干燥、材料科学和质热传递等物理化学过程。本文就液体物料冷冻干燥过程做了简要评述,并对其过程的热点问题做了分析。Freeze drying or lyophilization of aqueous solutions is widely used in pharmaceutical industry. The increased importance of the process is gaining a worldwide interest of research. A growing body of literature has demonstrated that the scientific approach can result in improved product quality with minimum trial and error empiricism. Formulation and development of processing technology need a systematical understanding of the physical chemistry of freezing and freeze drying, material science and mechanisms of heat and mass transfer. This paper presents an overview on process of freeze drying of aqueous solutions. The study hotspots of the process are analyzed.

关 键 词：共晶形成 玻璃化转变 赋形剂 传质传热 解析 

分 类 号：TS255[轻工技术与工程—农产品加工及贮藏工程]