内皮屏障与极性运输  

Endothelial Barrier and Polarized Transportation

作　　者：李海韵[1] 吉尚戎[1] 

机构地区：[1]兰州大学生命科学学院,兰州730000

出　　处：《生物物理学报》2013年第6期397-406,共10页Acta Biophysica Sinica

基　　金：国家自然科学基金项目(30930024)~~

摘　　要：极化细胞的极性分布和功能行使,需要不同机制相互协作,改变胞内蛋白的运输和分布,并对环境变化做出极性应激。内皮细胞(endothelial cells,ECs)是一类具有极性特征的单层特化上皮细胞,在结构和功能上形成面向血液的顶端区域(apical membrane domain)和面向下方平滑肌细胞的基底侧区域(basolateral membrane domain)。内皮功能障碍和细胞极性丢失,与心血管疾病及癌症的发生紧密相关。在炎症和免疫应答中,内皮细胞通过胞内蛋白的持续分选维持极性,协助血液中大分子跨过内皮屏障完成生理功能,同时,对血液或组织中的生理变化做出极性应答。The polarized distribution of functions in polarized cells requires the coordinated interaction of multiple mechanisms, such as intracellular protein trafficking, asymmetry distribution and polarized responds to extracellular changes. Endothelial cells （ECs） are monolayer of specialized epithelia with polarity, showing structurally and functionally distinct apical domain orienting toward blood and basolateral domain facing smooth muscle cells. Endothelial dysfunction and defects in polarity are closely associated with cardiovascular disease and cancer. In inflammation and immune response, endothelial cells maintain their polarization through continual intracellular protein sorting, facilitate the transcellular transport of macromolecules in blood across endothelial barrier and show polarized responds to physiological change in blood or interstitial fluid.

关 键 词：内皮屏障 细胞极性 膜运输 

分 类 号：Q946.885.1[生物学—植物学]