胰高血糖素样肽1及其受体在代谢外科手术治疗机制中的作用  

The role of glucagon-like peptide-1 and its receptor in the mechanism of metabolic surgery

作　　者：郑志海[1] 王小坤[2] 朱恒梁[1] 郑晓风[1] 蒋飞照[1] 

机构地区：[1]温州医学院附属第一医院腔镜外科,325000 [2]湖北省荆门市第一人民医院胆胰血管外科

出　　处：《中华胃肠外科杂志》2013年第9期907-910,共4页Chinese Journal of Gastrointestinal Surgery

基　　金：浙江省温州市科学技术委员会（国际合作课题）（H20090034）

摘　　要：目前外科手术已经成为治疗2型糖尿病治疗方式之一,但对于其治疗机制仍然还不明确.很多试验证明,糖尿病外科手术以后,解剖生理结构的改变导致了与代谢有关胃肠道分泌的激素和神经肽类分子水平的明显变化,这些分子在功能上与葡萄糖代谢、胰岛细胞功能、胰岛素敏感性相关,其中研究较为深入的是胰高血糖素样肽 -1（gucagon-like peptide-1 GLP-1）,其在外科手术治疗糖尿病中所起的重要作用已得到人们越来越多的认可.而GLP-1必须与GLP-1受体（GLP-1 receptor GLP-1R）结合后才能发挥其生理作用.本文就GLP-1及其受体在代谢外科手术治疗机制中的作用作一综述.At present,surgery has become one of the treatments for type 2 diabetes,but it is still unclear about the therapeutic mechanism.Many experiments has proved that the anatomical and physiological structure has been altered leading to significant changes related to the secretion of gastrointestinal hormones and neuropeptides.These molecular are related to the metabolism of glucose,functions of islet cells and sensitivity of insulin.Intensive studies of glucagon-like peptide-1 （GLP-1） play an important role in the surgical treatment of diabetes and now it has gained increasing recognition.However,GLP-1 must be combined with GLP-1 receptor （GLP-1R） to execute its function.In this paper we reviewed the role of GLP-1 and its receptor in the mechanism of metabolic surgery.

关 键 词：胰高血糖素样肽-1 糖尿病 2型 吻合 术 外科 血糖 胰岛素 

分 类 号：R587.1[医药卫生—内分泌]