声触诊组织定量分析在2型糖尿病肾病分期诊断中的价值  

Value of virtual touch tissues quantization in the stages of type 2 diabetic nephropathy

作　　者：于宁[1] 杨雪[1] 刘春晖[1] 王正滨 禹静[1] 

机构地区：[1]青岛大学医学院附属医院超声科,266003 [2]黄岛分院超声诊疗科

出　　处：《中华超声影像学杂志》2013年第8期680-683,共4页Chinese Journal of Ultrasonography

基　　金：山东省高等学校科技计划项目（J12LL08）

摘　　要：目的探讨声触诊组织定量分析（VTQ）在2型糖尿病。肾病分期中的应用价值。方法根据尿白蛋白排泄率（uAER）将120例2型糖尿病患者分为3组：单纯糖尿病组、微量白蛋白尿组、临床蛋白尿组，另选择30例健康体检者作为对照组，利用VTQ检测4组的肾实质剪切波速度（SWV），比较各组间肾实质SWV的变化。并将糖尿病组的SWV与其UAER进行相关分析。结果单纯糖尿病组与对照组SWV比较差异无统计学意义（P=0．144），其他两组与对照组SWV比较差异均有统计学意义（P〈0．05）；糖尿病各组间两两比较SWV差异也均有统计学意义（P〈0．05）。糖尿病组的SWV与其UAER存在显著正相关（r=0．697，P〈0．05）。VTQ鉴别糖尿病是否发生肾损害的ROC曲线下面积为0．93，最佳截断点为2．43m／s，敏感性为85．7％，特异性为84．5％。结论2型糖尿病患者swV随肾损害程度加重而增快；VTQ测量。肾实质SWV在糖尿病肾病分期诊断中具有重要价值。Objective To investigate the application value of virtual touch tissues quantization（VTQ） in the stages of type 2 diabetic nephropathy. Methods 120 cases of type 2 diabetes were divided into 3 groups according to urinary albumin excretion rate （UAER）.. diabetes without urinary albumin, diabetes with trace albuminuria and diabetes with mass albuminuria. The control group consisted 30 normal cases. VTQ was used to measure the renal shear wave velocity （SWV）, then compare were made between the 4 groups. Besides, correlation analysis was made between SWV and UAER in diabetic nephropathy group. Results When compared SWV, there was no significant difference between diabetes without urinary albumin and control group （ P = 0. 144）, but there was significant difference between each 2 group of diabetes with trace albuminuria, diabetics with mass albuminuria group and control group （P 〈0.05）. There was also significant difference between each 2 group of diabetes （P 〈 0.05）. The correlation coefficients for SWV and UAER in diabetes were 0. 697（ P〈0.05）. ROC analyses showed the area under curves for SWV diagnosis for diabetic nephropathy was 0.93. The best cutoff point, sensitivity and specificity were 2.43 m/s, 85.7 %and 84.5%, respectively.Conclusions The renal SWV increases as the renal injury progresses,which also plays an important role in diabetic nephropathy stages.

关 键 词：超声检查 糖尿病肾病 声触诊组织定量分析 

分 类 号：R445.1[医药卫生—影像医学与核医学] R587.2[医药卫生—诊断学] R692.9[医药卫生—临床医学]