血清抗Sm抗体与儿童系统性红斑狼疮临床表现与疾病活动性相关分析  

Associations of anti-Smith antibo dies with clinical manifestations and disease activity in children with systemic lupus erythematosus

作　　者：庄捷秋[1] 陈方旋[1] 金宛宛[2] 杨青[1] 高宇[2] 

机构地区：[1]温州医学院附属第二医院、育英儿童医院儿童肾内科,325027 [2]温州医学院附属第二医院、育英儿童医院皮肤科,325027

出　　处：《中华皮肤科杂志》2013年第9期667-669,共3页Chinese Journal of Dermatology

摘　　要：目的探讨血清抗Sm抗体与儿童系统性红斑狼疮（SLE）临床表现和疾病活动度之间的相关性。方法根据SLE疾病活动指数（SLEDAI）评分将72例SLE患儿分成无活动组和活动组，用免疫印迹法检测患儿的血清抗Sm抗体，分析抗Sm抗体与SLE临床表现和疾病活动度之间的关系。结果72例SLE患儿中无活动组28例（38．9％），活动组44例（61．1％）。血清抗Sm抗体阳性17例（23．6％），阴性55例（76．4％）。抗Sm抗体阳性者肾损害的发生率（70．6％，12／17）高于抗Sm抗体阴性者（41．8％，23／55），差异有统计学意义（P〈0．05）。活动组抗Sm抗体阳性14例（31．8％，14144），无活动组抗Sm抗体阳性3例（10．7％，3／28），两组比较差异有统计学意义（P〈0．05）。结论血清抗Sm抗体不仅是SLE患儿临床诊断的重要指标，同时也是SLE病情活动及肾脏损害的危险因素。Objective To assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in children with systemic lupus erythematosus （SLE）. Methods According to SLE disease activity index （SLEDAI） score, 72 children with SLE were divided into the active group and inactive group. An immunoblotting method was used to detect serum anti-Smith antibodies in these subjects. Chi-square test was conducted to assess the associations of anti-Smith antibodies with clinical manifestations and disease activity in these patients. Results Of these patients, 28 （38.9%） were assigned into the inactive group, and 44 （61.1%） to the active group. Anti-Smith antibodies were detected in 17 （23.6%） patients, but not in the other 55 （76.4%） patients. Elevated incidence rate of kidney injury was observed in anti-Smith antibody-positive patients compared with anti-Smith antibody-negative patients （70.6% （12/17） vs. 41.8% （23/55）, P 〈 0.05）. Meanwhile, the positivity rate of anti-Smith antibodies was 31.8% （14/44） in the active group, significantly higher than that in the inactive group （10.7%, 3/28, P 〈 0.05）. Conclusions Anti-Smith antibodies are not only an important indicator for the diagnosis of SLE, but also a risk factor for disease exacerbation and kidney injury in children with SLE.

关 键 词：抗SM抗体阳性 系统性红斑狼疮 临床表现 SLE疾病活动指数 疾病活动性 血清 相关分析 儿童 

分 类 号：R725.9[医药卫生—儿科]