CHILD综合征的临床、病理及免疫组化特征  

Clinicopathological and immunohistochemical characteristics of CHILD syndrome

作　　者：邱贤文[1] 米向斌[1] 郭琳琅 

机构地区：[1]南方医科大学珠江医院皮肤科,广州510282 [2]病理科

出　　处：《国际皮肤性病学杂志》2013年第5期277-279,共3页International Journal of Dermatology and Venereology

摘　　要：患者女，9岁。左侧躯体皮肤红色斑丘疹、斑块伴左下肢畸形9年就诊。体检：患者跛行，左下肢较右侧明显短小，左足2、3、4趾畸形。左侧肢体肌张力下降，肌力较对侧弱。皮肤科检查：左侧后颈部、臀部、会阴部、小腿、足部明显红色肥厚性斑块。皮损组织病理检查：表皮角化过度，真皮乳头少量泡沫细胞浸润，真皮浅层灶性淋巴细胞和浆细胞浸润。免疫组化检查：真皮乳头泡沫细胞CD68、CD163强阳性，但不表达S100。诊断为CHILD综合征。A 9-year-old girl was born with cutaneous erythema and plaques on the left side of the body as well as deformity of the left lower limb. Physical examination revealed limp, obvious shortening of the left lower limb, deformity of the second, third and fourth toes of the left foot. Both muscle tone and muscle strength were decreased in the left lower limb compared with the right lower limb. Cutaneous examination showed erythematous hypertrophic plaques in the left posterior neck, buttock, perineum, leg, and foot. Histopathologic examination of the skin lesions showed epidermal hyperkeratosis, a small number of foamy cells infiltrating the dermal papillae, as well as focal lymphocyte and plasma cell infiltrates in the superficial dermis. Moreover, the foamy ceils in the dermal papillae stained strongly positive for CD68 and CD163, but negative for S100. A diagnosis of CHILD syndrome was made.

关 键 词：CHILD综合征 病理学 免疫组织化学 

分 类 号：R758.502[医药卫生—皮肤病学与性病学]