盐酸氨溴索辅助治疗老年人社区获得性肺炎的临床研究  

Clinical study of intravenous ambroxol as adjunctive therapy in elderly patients with community acquired pneumonia

作　　者：李勇[1] 吴峰[1] 

机构地区：[1]福建医科大学附属协和医院呼吸内科,福州350000

出　　处：《中华老年医学杂志》2013年第9期948-950,共3页Chinese Journal of Geriatrics

摘　　要：目的探讨盐酸氨溴索静脉滴注辅助治疗老年人社区获得性肺炎（CAP）的临床疗效。方法选择2010年5月至2012年8月在我院住院的老年CAP患者120例，随机分为3组：对照组40例，仅给予抗生素、吸氧等治疗；小剂量治疗组40例，给予盐酸氨溴索15mg，3次/d静脉滴注，余治疗与对照组相同；常规剂量治疗组40例，给予盐酸氨溴索30mg，3次/d静脉滴注。3组患者均治疗7d，动态监测患者血白细胞、超敏C反应蛋白（hs—CRP）、降钙素原（PCT）含量。结果治疗7d后，小剂量治疗组40例患者显效、有效、无效分别为25例（62．5％）、6例（15．0％）、9例（22．5％），总有效率77．5％；常规剂量治疗组40例患者分别为33例（82．5％）、6例（15．0％）、1例（2．5％），总有效率97．5％；对照组分别为16例（40．0％）、6例（15．0％）、18例（45．0％），总有效率55．0％。小剂量治疗组和常规剂量治疗组患者的显效率和总有效率均高于对照组（x^2=15．29、20．22，均P〈0．05），两治疗组比较，差异也有统计学意义（x^2=1．01、7．31，均P〈0．05）。治疗后3组患者血白细胞、hs—CRP、PCT水平较治疗前均降低（均P〈20．05）；与对照组比较，两治疗组降低更明垃，尤以常规剂量治疗组最明屉（均P〈0．05）。结论应用常规剂量盐酸氨溴索（30mg，3次／d）静脉滴注治疗老年人GAP有较好的疗效。Objective To evaluate the efficacy of ambroxol on community acquired pneumonia （CAP） in elderly patients. Methods Totally 120 patients with CAP were selected and divided into 3 groups： low-dose group （patients received amhroxol 15 mg intravenously, 3 times per day, n 40）, conventional-dose group （patients received ambroxol 30 mg intravenously, 3 times per day, n=40） and control group （patients received routine treatment including antibiotic therapy and oxygen inhalation, n 40）, All patients were treated for ？ days. The levels of white blood cell （WBC）, high sensitivity C-reactive protein （hs-CRP） and procalcitonin （PCT） were determined dynamically during the treatment. Results The markedly efficient rate, efficient rate and inefficient rate were 62.5% （25/40）, 15.09/00 （6/40） and 22.5G （9/40） in low-dose group, 82.5% （33/40）, 15.0% （6/40） and 2.5% （1/40）in conventional dose group, 40% （16/40）, 15.0% （6/40） and 45.0% （18/40） in control group, respectively. The total efficient rates were 77.5%, 97.5% and 55.0% in lowdose, conventional-dose and control groups, respectively. The markedly efficient rate was higher in low dose, conventional-dose groups than in control group （x^2=2 15.29, P〈0.05）. There was a significant difference in markedly efficient rate between low-dose and conventional dose groups （x^2=4.01,P〈 0.05 ）. The total efficient rate was higher in low-dose, conventional-dose groups than in control group （x^2= 20.22 ,P〈0.05）. There was a significant difference in total efficient rate between low--dose and conventional-dose groups （x^2==7.31,P〈0.05）. Compared with before treatment, the levels of WBC, hs-CRP and PCT were decreased in 3 groups after treatment （all P〈0.05）. The levels of WBC, hs CRP and PCT were decreased more remarkably in low-dose, conventional-dose groups than in control group （all P〈0.05）. There was a significant levels between low dose and conventional-dose difference in the decrease of

关 键 词：氨溴索 社区获得性感染 

分 类 号：R563.1[医药卫生—呼吸系统]