川芎嗪注射液及丹红注射液联合可吸收生物膜预防肌腱粘连的临床研究  

Danhong Injection,Ligustrazine Injection,Combined Adsorbable Biomembranes Prevented Adhesion of Tendons after the Repair Operation:a Clinical Research

作　　者：赵治伟[1] 程春生[1] 马文龙[1] 单海民[1] 程真真[1] 宋冠鹏[1] 

机构地区：[1]河南省洛阳正骨医院,河南471002

出　　处：《中国中西医结合杂志》2013年第9期1212-1215,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：河南省省属科研单位社会公益专项资金项目

摘　　要：目的探讨川芎嗪注射液及丹红注射液与可吸收生物膜联合应用预防肌腱及组织粘连的有效性及作用机制。方法选择120例患者(均为利器导致的手部二区单纯屈指肌腱断裂),按随机数字表法分为迪康组(A组)、天新福组(B组)、天新福加川芎嗪组(C组)、天新福加丹红组(D组),每组30例。观察手部肌腱总主动活动度(total active movement,TAM),测定明尼苏达手灵巧度系统(Minnesota manual dexterity test,MMDT)、指抓屈力量(finger flex strength test,FFST)。结果术后4、8周C、D组TAM及优良率均高于A、B组(P<0.05,P<0.01);C、D组比较差异无统计学意义(P>0.05)。C、D组MMDT各指标均低于A、B组(P<0.05)。4组FFST比较差异无统计学意义(P>0.05)。结论川芎嗪注射液或丹红注射液与天新福可吸收生物膜联合应用均可有效预防肌腱粘连,丹红注射液与川芎嗪注射液疗效相当,且明显优于单独应用迪康可吸收膜及天新福可吸收生物膜。Objective To explore the effect and the mechanism of Danhong Injection （DI）, Ligu- strazine Injection （LI）, and adsorbable biomembranes in preventing the adhesion of tendons and tissues. Methods Totally 120 patients all suffering from simple flexor digitorium tendon rupture on the hand zone two damaged by sharp weapons were randomly assigned to Group A （Dikang adsorbable biomembrane）, Group B （Tianxinfu adsorbable biomembrane）, Group C （Tianxinfu adsorbable biomembrane ＋ Ligus- trazine group）, and Group D （Tianxinfu adsorbable biomembrane ＋ DI group） in accordance with random digit table, 30 cases in each group. Indicators such as total active movement （TAM） of the hand tendon, Minnesota manual dexterity test （MMDT）, and finger flex strength test （FFST）were observed. Results The TAM and the favorable rate were higher in Group C and D than in Group A and B at post-operative 4 and 8 week （P 〈0.05,P 〈0.01）. There was no statistical difference between Group C and D （P 〉0.05）. Each index of MMDT was lower in Group C and D than in Group A and B （P 〈0.05）. There was no statisti- cal difference in FFST among all the 4 groups （P 〉0.05）. Conclusions Combined application of LI or DI with Tianxinfu adsorbable biomembranes could effectively prevent the adhesion of tendons. DI showed e- quivalent effect as LI did. Besides, the combined application was superior in preventing adhesion to using Xintianfu adsorbable biomembrane or Dikan adsorbable biomembrane alone.

关 键 词：川芎嗪注射液 丹红注射液 天新福可吸收生物膜 迪康可吸收生物膜 肌腱粘连 

分 类 号：R274[医药卫生—中医骨伤科学]