持续短阵快速脉冲刺激前额叶皮质对视空间注意功能的调控机制  

Modulatory effects of continuous theta burst stimulation over dorsolateral prefrontal cortex on visuospa tial attention

作　　者：徐光青[1] 兰月[2] 赵江莉[1] 陈正宏[1] 黄东锋[1] 

机构地区：[1]中山大学附属第一医院康复医学科,广州510080 [2]中山大学附属第三医院康复医学科

出　　处：《中国康复医学杂志》2013年第9期806-810,共5页Chinese Journal of Rehabilitation Medicine

基　　金：国家自然科学基金资助项目(81071608)

摘　　要：目的:探讨持续短阵快速脉冲刺激背外侧前额叶皮质对视空间注意功能的调控机制。方法:选取志愿受试者40人参加本实验,男女各半,全部为右利手。采用持续短阵快速脉冲经颅磁刺激(cTBS,TMS)背外侧前额叶皮质(DLPFC)后进行注意网络测试(ANT),所有受试者均按照随机顺序进行真/假刺激左/右侧背外侧前额叶脑区。结果:持续短阵快速脉冲经颅磁刺激施加于前额叶时,不同提示和刺激类型的平均反应时均无明显改变。右侧额叶抑制,警觉和执行功能受损(P<0.05);左侧额叶抑制,反而出现警觉和执行功能增强(P<0.05)。结论:背外侧前额叶皮质主要与警觉和执行功能有关,具有明显的右侧半球优势。在双侧大脑半球同源脑区间,视空间注意认知过程存在竞争性抑制。Objective： To probe the prefrontal cortex （ DEPFC ） man subjects. modulatory effects of continuous theta burst stimulation（cTBS） over the dorsolateral on visuospatial attention using attention network test （ANT） paradigm in healthy hu- Method： ANT was used to test forty healthy subjects after cTBS on the left or right DLPFC. The ANT pro- vided measures for three different components of visual attention： alerting, orienting and executive control. Result： During this task, subjects with real left-DLPFC cTBS showed significant improvement in network ef- fect indices compared with the shams on alerting and conflict, and significant deficit on orienting（P〈0.05）. Moreover, compared with the sham cTBS condition, the real right-DLPFC cTBS resulted in significant decreas- es in efficiency of alerting and conflict,and significant increase in orienting index （P〈0,05 ）.Furthermore, there were significant differences in alerting,orienting and conflict effect indices between in the real left-DLPFC and in the right-DLPFC. Conclusion： These results suggest that right DLPFC plays a pivotal role in alerting and executive control pro- cess. In addition, the present study supports the model of inter-hemispheric rivalry for visuospatial attention. Author＇s address Dept. of Rehabilitation Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510080

关 键 词：视空间注意 前额叶 短阵快速脉冲刺激 经颅磁刺激 

分 类 号：R338[医药卫生—人体生理学]