PLZF与哺乳动物雄性生殖干细胞的发育分化  

Functions of PLZF in Male Germline Stem Cell Development and Differentiation

作　　者：宋文聪[1] 华进联[1] 

机构地区：[1]西北农林科技大学动物医学院、陕西省干细胞工程技术研究中心、农业部动物生物技术重点开放性实验室,陕西杨凌712100

出　　处：《中国生物化学与分子生物学报》2013年第9期825-832,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金面上项目(No.31272518);教育部博士点基金(No.RFDP,20120204110030)~~

摘　　要：早幼粒细胞白血病锌指蛋白(promyelocytic leukemia zinc finger,PLZF),也被称为ZBTB16(zinc finger and BTB domain containing 16,ZBTB16)或锌指蛋白145(zinc finger protein 145,ZFP145),是我国学者发现与人类疾病相关的蛋白质.人类PLZF的是由673个氨基酸残基组成的转录抑制因子,属于蛋白质超家族.该超家族以N端的BTB/POZ(bric-à-brac,tramtrack,brad complex(BTB)/poxvirus zinc finger(POZ)domain)结构为特征.PLZF蛋白的BTB/POZ结构与个体发育、胚胎发生、染色体的重构等事件相关.近年发现,PLZF在哺乳动物雄性生殖干细胞(male germline stem cells,mGSCs)发育分化过程中也发挥重要作用.探讨PLZF的生物学功能和作用机制,将有助于理解其在mGSCs发育过程中的重要作用.本文就PLZF在维持mGSCs自我更新和在发育分化调控中的作用给予综述.The promyelocytic leukemia zinc finger （PLZF） protein, also known as ZBTB16 （zinc finger and BTB domain containing 16） or ZFP145 （zinc finger protein 145） , was first reported as a human disease-associated protein. The human PLZF belongs to the POK （POZ and Krtippel） protein super- family, a transcription repressor, and consists of 673 amino acids residures. PLZF is characterized by a N-terminal BTB/ POZ domain, which associated with various biological events, such as ontogenesis, embryogenesis and chromosomal remodeling. The function of PLZF in acute promyelocytic leukaemia （APL） in recent studies showed that it played a critical role in regulating mammal germline stem cells （mGSCs） development and differentiation. This review summarizes the latest advances about the roles of PLZF in maintaining and regulating mGSCs self-renewal and differentiation and provides helpful information to further understand the mGSCs development.

关 键 词：早幼粒细胞白血病锌指蛋白(PLZF) 雄性生殖干细胞 自我更新 发育 分化 哺乳动物 

分 类 号：Q2[生物学—细胞生物学] Q7