Effect of ventricular leads position on the clinic outcome of cardiac resynchronization therapy  

作　　者：DONG Ying-xue Boodhna Javin YANG Yan-zong 

机构地区：[1]Department of Cardiology, First Affiliated Hospital of Dalian MedicalUniversity, Dalian, Liaoning 116011, China

出　　处：《Chinese Medical Journal》2013年第16期3161-3164,共4页中华医学杂志（英文版）

基　　金：This project was supported a grant from the National Natural Science Foundation of China （No. 81200137）.

摘　　要：Cardiac resynchronization therapy （CRT） is an effective treatment for heart failure patients with severely obvious left ventricular ejection fraction （LVEF） and evidence of cardiac dyssynchrony.1-3 With conventional biventricular stimulation,notable left ventricular （LV） reverse remodeling,the most reliable predictor of long-term survival in CRT patients,is achieved in only 60%-70% of the patients.4,5 Lack of LV dyssynchrony,non-optimal position of the LV pacing lead,high-myocardial scar burden,and sub-optimal device programming have been related to non-response to CRT.6-8 Particularly,the optimal placement of LV lead in a tributary of the coronary sinus is one of the most challenging technique of CRT device implantation.This article will discuss the effect of ventricular leads on the clinic outcome after CRT and how to locate the optimal ventricular leads to maximize the haemodynamic benefits of CRT and provide superior longterm outcome.Cardiac resynchronization therapy （CRT） is an effective treatment for heart failure patients with severely obvious left ventricular ejection fraction （LVEF） and evidence of cardiac dyssynchrony.1-3 With conventional biventricular stimulation,notable left ventricular （LV） reverse remodeling,the most reliable predictor of long-term survival in CRT patients,is achieved in only 60%-70% of the patients.4,5 Lack of LV dyssynchrony,non-optimal position of the LV pacing lead,high-myocardial scar burden,and sub-optimal device programming have been related to non-response to CRT.6-8 Particularly,the optimal placement of LV lead in a tributary of the coronary sinus is one of the most challenging technique of CRT device implantation.This article will discuss the effect of ventricular leads on the clinic outcome after CRT and how to locate the optimal ventricular leads to maximize the haemodynamic benefits of CRT and provide superior longterm outcome.

关 键 词：cardiac resynchronization therapy lead position clinic outcome 

分 类 号：Q463[生物学—生理学] TU973.19[建筑科学—结构工程]