自身免疫性肝病相关自身抗体谱的检测和临床意义  

Diagnostic and predictive significance of autoantibody profiles in autoimmune liver disease

作　　者：唐劼 卢洁 闫惠平[2] 

机构地区：[1]北京欧蒙生物技术有限公司,北京市100101 [2]首都医科大学附属北京佑安医院感染与免疫研究中心,北京市100069

出　　处：《世界华人消化杂志》2013年第25期2544-2550,共7页World Chinese Journal of Digestology

基　　金：首都卫生发展科研专项基金资助项目;No.首发2011-2018-05~~

摘　　要：自身免疫性肝病(autoimmune liver disease,A I L D)是一组因为肝脏免疫耐受机制失衡引起的肝细胞或胆管上皮细胞的慢性损伤性炎症,是肝硬化和肝功能障碍的常见原因之一.利用间接免疫荧光法(indirect immunofluorescence,IIF)和抗原特异性检测方法,进行自身抗体的筛查和确认,是AILD病因学诊断的重要方法.新的靶抗原的发现和鉴定丰富了AILD自身抗体谱的组成,也拓展了自身抗体检测的临床应用范围.作为生物标记物,自身抗体的临床意义不仅体现在自身免疫性疾病的诊断上,在反映疾病活动性和严重程度、评价病情演进过程、疗效监测和预后判断等方面也发挥着越来越重要的作用.Autoimmune liver disease （AILD） is a chronic inflammatory disease presumably induced by a disorder of immune homeostasis within the liver, which can lead to damage to or loss of the hepatic parenchyma or bile duct epithelia. Indirect immunofluorescence and antibody specificity assays are important tools for the diagnosis of AILD. Over the last decade, there have been an increasing number of newly characterized target antigens for autoantibodies in AILD. Autoantibodies, as biomarkers, are used not only for disease diagnosis, but also for monitoring disease activity and progression and predicting prognosis and treatment responses.

关 键 词：自身免疫性肝炎 原发性胆汁性肝硬化 自身抗体 

分 类 号：R446.6[医药卫生—诊断学]