儿童肠道病毒71型活动性感染与红细胞锌浓度的相关性  

Correlation between active enterovirus type 71 infection and erythrocyte zinc concentration in children

作　　者：刘自刚[1] 李海波[1] 王少敏[1] 徐凤兰[1] 

机构地区：[1]孝感市中心医院,湖北省孝感市432000

出　　处：《世界华人消化杂志》2013年第25期2620-2622,共3页World Chinese Journal of Digestology

基　　金：湖北省自然科学基金资助项目;No.2011CDB324~~

摘　　要：目的:探讨儿童肠道病毒71型(enterovirus type71,EV71)活动性感染与患儿红细胞锌浓度的关系.方法:用金标法筛查儿童感染EV71-IgM阳性率,并用火焰原子吸收光谱法对患儿红细胞锌浓度进行测定,并对实验数据进行相应的统计分析.结果:EV71-IgM(+)组红细胞锌(83.7 mol/L±30.1 mol/L)低于EV71-IgM(-)组(100.6 mol/L±40.2 mol/L)(P<0.05),EV71-IgM(+)治愈率与红细胞锌浓度值呈正相关(P<0.05),均有显著差异.结论:人体红细胞锌水平对EV71病毒活动性感染儿童的发病和疗效均有显著影响.AIM： To explore the correlation between active enterovirus type 71 （EV71） infection and erythrocyte zinc concentration in children. METHODS： Three hundred and ninety-two children who had hand foot and mouth disease were included in this study. Twenty normal children were used as controls. EV71-IgM was detected in the children using the gold standard method. Erythrocyte zinc concentration was measured using flame atomic absorption spectrometry. The correlation between active EV71 infection and erythrocyte zinc concentration was then analyzed. RESULTS： The erythrocyte zinc concentration was significantly lower in the EV71-IgM（＋） group than in the EV71-IgM（-） group （83.7 μmol/L ± 30.1 μmol/L vs 100.6 μmol/L ± 40.2 μmol/L, P 〈 0.05）. The negative conversion of EV71-IgM （＋）was positively correlated with erythrocyte zinc concentration （P 〈 0.05）. CONCLUSION： Erythrocyte zinc concentration has a significant effect on susceptibility to and treatment of active EV71 infection in children.

关 键 词：肠道病毒71型 活动性感染 红细胞锌 

分 类 号：R725.1[医药卫生—儿科]