Hemophagocytic syndrome： a rare but fatal complication after liver transplantation  

作　　者：FU Bin-sheng YANG Yang LI Hua ZHANG Tong CHEN Gui-hua 

机构地区：[1]Liver Transplantation Center, Third Affiliated Hospital of Sun Yat- sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, Guangdong 510630, China

出　　处：《Chinese Medical Journal》2013年第18期3587-3589,共3页中华医学杂志（英文版）

摘　　要：Hemophagocytic syndrome （HPS） is recognized as a disorder characterized by a variety of symptomsincluding fever, jaundice, skin rash, lymphadenopathy, and hepatosplenomegaly related to uncontrolled systemic T-cell activation. Two forms of HPS have been characterized： primary/familial hemophagocytic lymphohistiocytosis and secondary/reactive HPS. Reactive HPS was first described in 1979 by Risdall et al.2 Although most patients with HPS are immunocompromised, only a small number of patients with HPS have been reported following liver transplantation （LT）, suggesting a low level of awareness for this hematological disorder after transplantation. We herein report one patient who underwent LT and in whom HPS subsequently developed. The patient had an aggressive clinical course and fatal outcome. The observation of one case of HPS in a cohort of 741 patients who underwent LT in our center raised the possibility that the case of HPS in these immunocompromised patients might be increasing in the future. Because of this,Hemophagocytic syndrome （HPS） is recognized as a disorder characterized by a variety of symptomsincluding fever, jaundice, skin rash, lymphadenopathy, and hepatosplenomegaly related to uncontrolled systemic T-cell activation. Two forms of HPS have been characterized： primary/familial hemophagocytic lymphohistiocytosis and secondary/reactive HPS. Reactive HPS was first described in 1979 by Risdall et al.2 Although most patients with HPS are immunocompromised, only a small number of patients with HPS have been reported following liver transplantation （LT）, suggesting a low level of awareness for this hematological disorder after transplantation. We herein report one patient who underwent LT and in whom HPS subsequently developed. The patient had an aggressive clinical course and fatal outcome. The observation of one case of HPS in a cohort of 741 patients who underwent LT in our center raised the possibility that the case of HPS in these immunocompromised patients might be increasing in the future. Because of this,

关 键 词：bone marrow biopsy hemophagocytic syndrome INFECTION liver transplantation PANCYTOPENIA 

分 类 号：Q813[生物学—生物工程] Q959.223.5