Universal soldier： Pseudomonas aeruginosa -- an opportunistic generalist  

作　　者：Jeremy GROSS Ian J. PASSMORE Jade C. S. CHUNG Olena RZHEPISHEVSKA Madeleine RAMSTEDT Martin WELCH 

机构地区：[1]Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK [2]Department of Chemistry, Umed University, Umed 901 87, Sweden

出　　处：《Frontiers in Biology》2013年第4期387-394,共8页生物学前沿（英文版）

摘　　要：The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis （CF）. P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a ＂natural＂ ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen.The opportunistic pathogen Pseudomonas aeruginosa commonly causes chronic and ultimately deadly lung infections in individuals with the genetic disease cystic fibrosis （CF）. P. aeruginosa is metabolically diverse; it displays a remarkable ability to adapt to and successfully occupy almost any niche, including the ecologically complex CF lung. These P. aeruginosa lung infections are a fascinating example of microbial evolution within a ＂natural＂ ecosystem. Initially, P. aeruginosa shares the lung niche with a plethora of other microorganisms and is vulnerable to antibiotic challenges. Over time, adaptive evolution leads to certain commonly-observed phenotypic changes within the P. aeruginosa population, some of which render it resistant to antibiotics and apparently help it to out-compete the other species that co-habit the airways. Improving genomics techniques continue to elucidate the evolutionary mechanisms of P. aeruginosa within the CF lung and will hopefully identify new vulnerabilities in this robust and versatile pathogen.

关 键 词：Pseudomonas aeruginosa cystic fibrosis EVOLUTION adaptive radiation antibiotic resistance quorum sensing 

分 类 号：S858.315.1[农业科学—临床兽医学] S858.23[农业科学—兽医学]