盐酸头孢替安致Stevens-Johnson综合征  

Stevens-Johnson syndrome caused by cefotiam hydrochloride

作　　者：朱忠华[1] 朱辉娅[1] 凌云 

机构地区：[1]黄山市人民医院药剂科,245000 [2]安徽省宣城市绩溪县食品药品监督管理局

出　　处：《药物不良反应杂志》2013年第4期217-218,共2页Adverse Drug Reactions Journal

摘　　要：1例61岁女性患者因慢性胆囊炎急性发作给予盐酸头孢替安2g+0.9%氯化钠注射液100 ml,2次/d静脉滴注;泮托拉唑60 mg+0.9%氯化钠注射液100 ml,2次/d静脉滴注。第2天,患者体温升高,面部及四肢出现红斑样皮疹伴瘙痒。停用盐酸头孢替安,静脉注射地塞米松、肌内注射异丙嗪,无明显好转。第3天皮疹波及全身,伴喉头不适、颜面红肿、眼睑水肿、结膜充血。诊断为Stevens-Johnson综合征,停用泮托拉唑,继续行糖皮质激素和抗组胺治疗。第5天,眼睑水肿减轻。第6天,四肢皮疹明显减轻,颜面红肿消退。第9天,患者全身皮疹基本消退。A 61-year-old woman with acute episodes of chronic cholecystitis received an IV infusion of cefotiam hydrochloride 2.0 g in 0.9% sodium chloride injection 100 ml twice daily, and an IV infusion of pantoprazole 60 mg in 0. 9% sodium chloride injection 100 ml twice daily. On day 2, the patient＇s body temperature rose, erythematous skin rashes appeared on her face and extremities, accompanied by itching. Cefotiam hydrochloride was stopped. She was treated with IV dexamethasone and IM promethazine. The above symptoms did not markedly improve. On day 3, skin rashes spread over her entire body, accompanied by throat discomfort, facial swelling, palpebral edema, and conjunctival congestion. Stevens-Johnson syndrome was diagnosed. Pantoprazole was stopped, glucocorticoid and antihistamine treatment was continued. On day 5, palpebral edema was relieved. On day 6, rashes on her limbs was significantly improved and facial swelling disappeared. On day 9, her generalized rashes basically subsided.

关 键 词：头孢替安 Stevens—Johnson综合征 

分 类 号：R595.3[医药卫生—内科学]