丙戊酸钠致严重血小板减少  

Severe thrombocytopenia caused by sodium valproate

作　　者：赵慧[1] 赵颖[2] 甄健存[1] 赵兴山[2] 

机构地区：[1]北京积水潭医院药剂科,100035 [2]北京积水潭医院心内科,100035

出　　处：《药物不良反应杂志》2013年第4期226-227,共2页Adverse Drug Reactions Journal

摘　　要：1例87岁女性患者因抽搐和心动过缓给予注射用丙戊酸钠1200mg静脉持续泵入，20ml／h，1次／d。用药前患者血小板计数为214×10^9／L。用药8d后血小板计数降至63×10^9／L，停用注射用丙戊酸钠，改为口服丙戊酸钠缓释片500mg，1次／d。5d后患者血小板计数降至25×10^9／L。停用丙戊酸钠缓释片，输注血小板1U，口服氨肽素1000mg，3次／d。对症治疗8d后血小板计数升至160×10^9／L。An 87-year-old woman with convulsions and bradycardia received a continuous IV infusion of sodium valproate 1200 mg once daily by a pump at a rate of 20 ml per hour. Her platelet count was 214×10^9/L before treatment. Eight days after treatment, her platelet count decreased to 63×10^9/L. Sodium valproate injection was withdrawn and her therapy was changed to sustained-release sodium valproate tablets 500 mg/d once daily. Five days later, the patient＇s platelet count decreased to 25×10^9/L. Sustained-release sodium valproate tablets were withdrawn. The patient received platelet transfusion 1 U and amino-polypeptide tablets 1000 mg three times a day. After eight days of symptomatic treatment, the patient＇s platelet count increased to 160×10^9/L.

关 键 词：丙戊酸钠 血小板减少 

分 类 号：R595.3[医药卫生—内科学]