磁性介孔碳对吲哚美辛的吸附与释放行为研究  

Study on adsorption amount and release behavior of indomethacin on magnetic mesoporous carbons

作　　者：田勇[1] 钟国英[1] 王秀芳[1] 陈任宏[2] 

机构地区：[1]广东药学院药科学院,广东广州510006 [2]广东食品药品职业学院,广东广州510520

出　　处：《广东药学院学报》2013年第3期246-249,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省高等学校高层次人才项目(2011年度);广东省自然科学基金(S2012010009416);广东省科技计划项目(2012B020316007;2012A020602058);广东高校优秀青年培育项目(2012LYM_0085);广州市科技计划项目(11C56040725)

摘　　要：目的合成具有高比表面和孔容的磁性含铁介孔碳,并考察其吸附能力和体外释放行为。方法采用三嵌段共聚物F127(PEO_(106)-PPO_(70)-PEO(106))为软模板,Fe(NO_3)_3·9H_2O为磁源制备了Ⅰ-C-2-850、Ⅱ-C-2-850和Ⅲ-C-2-850 3种磁性介孔碳[Fe(NO_3)_3·9H_2O的质量分别为0.096 g、0.17 g和0.26 g],并以吲哚美辛作为模型药物,考察所合成的磁性介孔碳对吲哚美辛的吸附及释放行为。结果磁性介孔碳对吲哚美辛的吸附量随着磁性介孔碳比表面积和孔容升高而增大,在Ⅰ-C-2-850、Ⅱ-C-2-850和Ⅲ-C-2-850 3种材料上的吸附量分别为445、419、390 mg/g;释放行为具有2步释放过程,即初始的快速释放及随后的缓慢释放过程,释放速率随磁性介孔碳孔径增大而增加。结论磁性介孔碳对吲哚美辛的吸附量和释放行为主要和磁性介孔碳的比表面和孔容有关。Objective Magnetic Fe-containing mesoporous carbons with high surface areas and pore volume were synthesized to investigate the adsorption and release behavior. Methods Indomethacin was selected as drug model. The adsorption and release behavior of indomethacin on magnetic mesoporous carbons were investigated,wherein triblock copolymer F127 （PEOI06-PPO70-PEO106 ） as a template agent and hydrated iron nitrite as an iron source. Three kinds of magnetic mesoporous carbons [ I -C-2-850, II -C-2-850 and III-C-2-850 J were prepared corresponding to 0.096 g,0.17 g and 0.26 g Fe（NO3 ）3 · 9H2O- Results The adsorbed indomethaein amount increased with the increase of the specific surface area and pore volume of the materials. The value for I -C-2-850 was 445 mg/g,whereas 419 and 390 mg/g could be obtained for II-C-2-850 and III/-C-2-850, respectively. The adsorption capacity increased with the increase of the specific surface area and pore volume of the materials. The two-step release process involved a first fast release and then a slower release. The release rate of indomethaein increased with the increase of pore size. Conclusion The adsorption capacity and the release rate of indomethacin on magnetic mesoporous carbons were mainly the function of the specific surface area and pore size of the materials.

关 键 词：磁性介孔碳 吲哚美辛 吸附 释放 

分 类 号：R318.08[医药卫生—生物医学工程]