216例次抗癫痫药物血药浓度监测结果分析  

Analysis of serum antiepileptic drugs concentration in 216 cases

作　　者：江颖[1] 梁健健[1] 

机构地区：[1]广州市第一人民医院药剂科,广东广州510180

出　　处：《广东药学院学报》2013年第3期302-304,共3页Academic Journal of Guangdong College of Pharmacy

摘　　要：目的了解治疗药物血药浓度的监测(TDM)与抗癫药物(AEDs)临床疗效的关系,提高临床个体化用药的合理性。方法采用回顾性调查方法,对我院2012年2月—2013年2月运用均相酶放大免疫法(EMIT)测定的216例次(其中住院患者153例次)应用AED患者的血药浓度结果及其临床疗效进行分析、评价。结果住院患者AED应用的总有效率为68.7%,中毒患者为6.5%,联合用药的患者中,血药浓度高于或低于正常治疗浓度的患者比例达79.5%。结论在应用AED时,不仅应注意血药浓度监测,还应尽量避免多种药物联合应用,并结合其他因素调整用药方案以达到安全、有效、合理应用本类药物。Objective To observe the clinical therapeutic effect of antiepileptic drugs （AEDs） through the therapeutic drug monitoring （TDM）, and provide rationally individualized medication. Methods Serum concentrations of antiepileptic drugs in 216 patients from February 2012 to February 2013 were measured by homogeneous enzyme-multiplied immunoassay technique （EMIT）. Results The total efficiency of antiepileptic drugs was 68.7% ,and the ratio of poisoning patients reached to 6.5%. In patients with combined treatment, the ratio of which blood drug concentrations of AEDs was higher or lower than normal therapy was up to 79. 5%. Conclusion When antiepileptic drugs are applied, blood drug concentrations should be monitored and the combination of multiple drugs should be avoided.

关 键 词：抗癫痫药物 血药浓度监测 疗效 分析 

分 类 号：R96[医药卫生—药理学]