DMPP对于鸡胚血管形成的抑制作用  

Inhibitory effect of DMPP in the angiogenesis of chick embryo

作　　者：周秦[1] 何晓东[1] 亓翠玲[1] 李江超[1] 郭四美[1] 叶杰[1] 韩露[1] 王丽京[1] 

机构地区：[1]广东药学院基础学院,广东广州510006

出　　处：《广东药学院学报》2013年第3期322-325,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金面上项目(31271455)

摘　　要：目的研究1,1-二甲基-4-苯基哌嗪(1,1-dimethyl-4-phenyl piperazinium,DMPP)对于鸡胚发育期血管新生的作用。方法采用质量浓度为50μg/mL的DMPP溶液局部处理鸡胚绒毛尿囊膜(chickenchorioallantoic membrane,CAM)和鸡胚卵黄囊膜(yolk sac membrane,YSM)表面,分别用肉眼和显微镜观察与被测物作用后CAM膜上血管生成情况和YSM膜血管密度和生长率的变化。结果 DMPP能明显抑制CAM模型血管的生成和YSM模型的血管面积和密度的增长。结论 DMPP可抑制鸡胚血管的形成。Objective To investigate the role of 1,1-dimethyl-4-phenylpiperazinium （DMPP）in the angiogcnesis of early chick embryo. Methods The chicken chorioallantoie membrane （CAM） and yolk sac membrane （YSM） were treated with 50 μg/mL DMPP. The angiogenesis of CAM was observed visually. The vascular density and growth rate of YSM were examined by microscopy. Results DMPP obviously suppressed the angingenesis of CAM and decreased the vascular density and growth rate of YSM. Conclusion DMPP exhibits an inhibitory eflbet on the augiogenesis of chicken embryo.

关 键 词：DMPP 鸡胚绒毛尿囊膜 鸡胚绒毛卵黄囊膜 血管形成 

分 类 号：R965[医药卫生—药理学]