盐酸昂丹司琼体外抑菌作用的实验研究  

Effects of antibacterial activity of ondansetron in vitro

作　　者：黄晓晨[1] 唐琦峰[2] 顾成永[1] 殷祖进 

机构地区：[1]江苏苏州市立医院(北区)麻醉科,苏州215008 [2]江苏苏州明基医院麻醉科南京医科大学附属医院,苏州215009 [3]江苏昆山市第四人民医院外科,昆山215300

出　　处：《河南外科学杂志》2013年第5期22-24,共3页Henan Journal of Surgery

基　　金：昆山市科技发展项目(005211);苏州市科技发展项目(SYSD2011111)

摘　　要：目的观察盐酸昂丹司琼在体外对大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌抑菌作用的影响。。方法将盐酸昂丹司琼注射液用无菌生理盐水稀释至终浓度分别为0.5、0.25、0.125和0.0625 mg/mL,与大肠埃希杆菌、金黄色葡萄球菌、和铜绿假单胞菌培养,每个实验重复三遍,所有菌株的稀释的系列测定均进行两次。结果昂丹司琼对大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌均有明显的抑菌作用,昂丹司琼对大肠埃希菌的抑菌作用随着昂丹司琼浓度的增加而增加,至0.0625 mg/mL时仍有明显的抑菌作用(P<0.05)。昂丹司琼对金黄色葡萄球菌和铜绿假单胞菌的抑菌作用在昂丹司琼浓度为0.125 mg/mL时消失。结论昂丹司琼在体外可以抑制大肠埃希菌、金黄色葡萄球菌、铜绿假单胞菌的生长,对于预防麻醉相关的感染可能有一定的临床意义。Objective To study the effects of antibacterial activity of Ondansetron in vitro. Methods A Series of solutions including O. 5 mg/mL,0.25 mg/mL,O. 125 mg,/mL and 0. 0625mg,/mL Ondansetrnn as well as normal saline were mixed with standard bacterial inocula of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa. Every test does three times. Results Ondansetron inhibites the growth of Escherichia coli,Staphylococcus aureus and Pseudomonas aeruginosa. Ondansetron only inhibited Escherichia coli at a concentration of of O. 125 mg/mL（P 〈 O. 05 ）. Conclusion Ondansetron can inhibite the growth of Escherichia coli, Staphylococcus aureus and Pseudomonas aerugi- nosa in vitro

关 键 词：昂丹司琼 抑菌作用 

分 类 号：R619[医药卫生—外科学]