血清Th1／Th2相关细胞因子在丙型肝炎患者中的临床意义  

Changes of Serum Th1Th2 Cytokines Levels in Patients with Hepatitis C

作　　者：王飙[1] 赵和平[1] 于燕[1] 陈伯伦[1] 王林川[2] 

机构地区：[1]西安交通大学附属红会医院检验科,西安710054 [2]西安交通大学第一附属医院检验科,西安710061

出　　处：《现代检验医学杂志》2013年第4期74-75,共2页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨血清白细胞介素-2（IL-2）,白细胞介素-6 （IL-6）在丙型肝炎患者体内的变化及临床意义.方法 对临床确诊65例丙型肝炎（其中25例慢性丙肝,21例丙肝肝硬化,19例丙肝肝癌患者）和20例健康人群采用酶联免疫吸附法（ELISA）进行血清IL-2,IL-6水平的检测.结果 慢性丙肝、肝硬化、肝癌和正常人群IL-2,IL-6水平（pg/ml）分别为：51.64±2.34,40.43±2.47,30.64±2.43,87.38±1.93;33.78±4.17,40.54±2.66,45.49±1.81,27.75±1.99.与正常人群比较,丙型肝炎（40.90±2.41 pg/ml）患者血清IL-2水平是降低的（t=13.23,P〈0.05）;IL-6的水平（36.60±2.88 pg/ml）是升高的（t=9.27,P〈0.05）.其中血清IL-2水平随着病情的进展而降低（慢性丙肝组〉肝硬化组〉肝癌组,t=3.98,P〉0.05）;而IL-6含量随着病情的进展而升高（t=2.38,P〈0.01）.结论 IL-2和IL-6水平变化与丙肝致肝硬化和癌变有关.Objective To analyse the clinical significance of changes of serum IL-2,IL-6 （interleukin-2,interleukin-6） in pa- tientswith hepatitis C. Methods Detected the levers of IL-2 and IL-6 by using enzyme-linked immunosorbent assay （ELISA） in 65 patients with clinically diagnosed hepatitis C （including 25 patients with chronic hepatitis C,21 patients with liver cir- rhosis,liver cancer 19 cases） and 20 cases of healthy people. Results The levers of IL-2 and IL-6 in chronic hepatitis C,liver cirrhosis,liver cancer, healthy people were 51.64± 2.34 pg/ml, 40. 43 ±2.47 pg/ml, 30.64±2.43 pg/ml, 87.38 ±1.93 pg/ ml; 33. 78± 4. 17 pg/ml, 40. 54 ± 2.66 pg/ml, 45.49 ± 1.81 pg/ml, 27.75 ±1.99 pg/ml, respectively. Compared with the normal population,patients with hepatitis C serum IL-2 levels were reduced（t = 13.23, P〈0.05） and IL-6 levels were ele- vated （t= 9.27, P〈0. 05）. The levels of serum IL-2 decreased as the disease progresses （CHC〉cirrhosis〉 HCC,t= 3.98, P〉0.05）. The levels of IL-6 increased as the disease progresses （t=2.38,P〈0.01）. Conclusion The IL-2 and IL-6 chan- ges associated with HCV cause liver fibrosis and cancer.

关 键 词：慢性丙型肝炎 白细胞介素-2 白细胞介素-6 谷氨酸氨基转移酶 

分 类 号：R512.63[医药卫生—内科学] R392.11[医药卫生—临床医学]