不同中药组方对高尿酸血症大鼠的影响  

Effects of different traditional Chinese medicine prescription on hyperuricemic rats

作　　者：严群超[1] 罗淑文 王帅帅 

机构地区：[1]暨南大学医学院,广州510632 [2]广州蓝韵医药研究有限公司,广州510663

出　　处：《哈尔滨商业大学学报（自然科学版）》2013年第4期394-397,共4页Journal of Harbin University of Commerce：Natural Sciences Edition

摘　　要：研究不同中药组方对血尿酸及相关代谢指标水平的影响.将大鼠随机分为10组:模型对照组,阳性对照组,中药组方A、B、C、D高、低剂量组,利用氧嗪酸钾构建大鼠高尿酸血症模型,分别给药30 d.给药27 d后测定部分大鼠血清尿酸,以确定造模成功与否及样品是否有疗效.给药30 d后全部动物测定血糖(GLU)、总胆固醇(CHOL)、甘油三酯(TG)、尿素(UREA)、肌酐(CREA)、尿酸(UA)、肾脏指数等指标.与模型组比较,给药27 d后各样品组动物血清尿酸浓度均有所降低;给药30 d后,A、B、C样品高、低剂量组均能降低高尿酸血症模型大鼠的血尿酸水平;给药30 d后,各样品组GLU、CHOL、TG、UREA、CREA等指标水平均无明显变化;给药30 d后,A、B、C各样品高剂量组均能明显降低高尿酸血症模型大鼠的肾脏指数.A、B、C组样品均能降低高尿酸血症大鼠血尿酸水平,初步印象其对肾脏具有一定的保护作用.This paper observed the effects of different traditional Chinese medicine prescrip- tions on serum uric acid and the related metabolic index. Rats were divided into ten groups as follows： model group, control group, A, B, C, D sample groups （high -dose groups, low - dose groups）. Rat models of hyperuricemic were established by oteracil potassium and had administration for thirty days. To make sure the model success and have a curative effect, the level of uric acid was determined after twenty seven days. The levels of GLU, CHOL, TG, UREA, CREA , UA and the kidney index was determined after thirty days. Com- pared with model group, the UA of all TCD sample groups were decreased significantly after twenty seven days. Furthermore, the UA of A, B, C groups （ high - dose and low - dose groups） and the kidney index of A, B, C high - dose groups were decreased significantly at the day 30th , and the GLU, CHOL, TG, UREA, CREA levels of all groups had no significant difference. A, B,C groups could decrease the UA of hyperuricemic rats, they had a certain protective effect to the kidney for the first impression.

关 键 词：中药组方 高尿酸血症 血尿酸 

分 类 号：R285[医药卫生—中药学]