不同剂量的优甲乐对131I治疗后早发甲减的影响分析  

Affect analysis of different doses Euthyrox to early hypothyroidism ofter 131I treatment

作　　者：毛绍蓉 唐小玲[1] 

机构地区：[1]四川省内江市第二人民医院核医学科,四川内江641003

出　　处：《医学检验与临床》2013年第4期53-54,16,共3页Medical Laboratory Science and Clinics

摘　　要：目的：不同剂量的优甲乐（L-T4）对131I治疗甲亢后早发甲减的影响。方法：218例Graves病患者，按照随机分组分为3组，A组69例，单纯给予131I治疗作为对照组；B组78例，131I治疗后21天起用L-T425ug/d连续治疗20天；C组71例，131I治疗后21天起用L-T4100ug/d连续治疗20天；通过测定甲功观察131I治疗后早发甲减发生率及首次甲亢治愈率。结果：131I治疗后3月、6月、12月甲减的发生率及首次甲亢的治愈率A组分别为8.72%、12.33%、20.28%，81.16%；B组分别为4.29%、5.49%、7.69%、76.92%；C组分别为4.37%、5.02%、7.04%、61.97%。结论：小剂量的优甲乐能降低131I治疗后早发甲减的发生率，同时甲亢的治愈率又不下降。Objective：to study the impact of interference on the 131I treatment used to treat hyperthyrosis through different does of Euthyrox （L-T4 ）on the early hypothyroidism. Methods：to divide the 218 samples of Graves disease patients into 3 random groups. Group A contained 69 samples, compared with the control group only treated by 131I;Group B had 78 samples, using 131I I for the first 21 day and L-T4 25ug/d for the next successive 20 days;Group C had 71 samples, using L-T4 100ug/d for a successive 20 days after the treatment in 131I for 21 days;The early hypothyroidism rate and the cure rate of hyperthyrosis were observed by measurement of thyroid function. Results：the early hypothyroidism rate and the cure rate of hyperthyrosis of group A after 3, 6, 12 months treated by 131I were 8.72%, 12.33%, 20.28%, and 81.16%respectively. Group B was 4.29%, 5.49%, 7.69%, and 76.92%. Group C was 4.37%, 5.02%, 7.04%, and 61.97%. Conclusions：smal does of Euthyrox could reduce the early hypothyroidism rate after using 131I I, and would not reduce the cure rate of hyperthyrosis.

关 键 词：甲减 GRAVES病 131I 优甲乐 

分 类 号：R972[医药卫生—药品]