米非司酮对早孕蜕膜及绒毛中雌孕激素受体的影响  

Effects on decidual and chorial estrogen and progestogen receptor in early pregnancy by mifepristone

作　　者：杨雪峰[1] 任芬若[1] 白桦[1] 翟子江[1] 

机构地区：[1]河南医科大学第三附属医院妇产科,郑州450052

出　　处：《中国实用妇科与产科杂志》2000年第10期605-606,共2页Chinese Journal of Practical Gynecology and Obstetrics

基　　金：河南省科技攻关计划项目! (编号 981170 10 2 )

摘　　要：目的　探讨米非司酮对早孕蜕膜及绒毛中雌激素受体 (ER)、孕激素受体 (PR)的影响。方法　取正常早孕人工流产、口服米非司酮并米索前列醇 (米索 )后各 15例患者的蜕膜及绒毛 ,应用单克隆抗体链霉菌抗生物素蛋白 -过氧化酶 (SP)免疫组织化学方法及CHAMPION系列数字图像处理系统观察ER、PR的变化。结果　人工流产组蜕膜ER阳性细胞百分比为 (6 1 13± 4 75 ) % ,PR为 (6 1 33± 5 45 ) % ;米非司酮并米索组蜕膜ER为(33 40± 2 6 4) % ,PR为 (33 78± 4 12 ) % ,两组差异有显著性 (P <0 0 0 5 )。人工流产组绒毛ER阳性细胞百分比为 (38 81± 4 31) % ,PR为 (31 13± 4 78) % ,而米非司酮并米索组绒毛ER、PR均无表达。结论　米非司酮可使早孕蜕膜及绒毛中ER、PR下降 。Objective\ To explore the effects of mifepristone on decidual and chorial estrogen receptor(ER)and progestogen receptor(PR)in early pregnancy.Methods\ 15 decidual and chorial ER and PR were observed respectively in ordinary induced abortion and treated by mifepristone and misoprotol P.O.with Streptavidin-Peroxidase(SP)methods and a series of CHAMPION digital draft processor.Results\ Decidual ER positive cell percentage in ordinary induced abortion was(16 13±4 75)%,PR was(61 33±5 45)%,decidual ER in treated by mifepristone and misoprostol P.O.was(33 40±2 64)%,PR was (33 78±4 12)%.There were significant difference in these two groups (P<0 005).Chorial ER positive cell percentage in ordinary induced abortion was(38 81±4 31)% and PR was(31 13±4 78)%.But chorial ER and PR did not expressed in treated by mifeprisone and misoprestol group.Conclusion\ Mifepristone could make decidual and chorial ER and PR expression less,which perhaps could be concerned with metorrhagia long time by drug induced abortion.

关 键 词：米非司酮 雌孕激素受体 药物流产 子宫出血 

分 类 号：R169.42[医药卫生—公共卫生与预防医学] R984