An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media  

作　　者：Fu-Jun Duan Jin-Chang Ding Hong-Juan Deng Ding-Ben Chen Jiu-Xi Chen Miao-Chang Liu Hua-Yue Wu 

机构地区：[1]College of Chemistry and Materials Engineering, Wenzhou University [2]Wenzhou Vocational and Technical College [3]College of Pharmaceutical and Chemical Engineering, Taizhou University

出　　处：《Chinese Chemical Letters》2013年第9期793-796,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(No.21172175);Natural Science Foundation of Zhejiang Province(Nos.LY12B02011 and Y4110491)for financial support

摘　　要：An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of β-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines （e.g., para-, metaor orthophenylenediamine） to construct bis-pyrrole or mono-pyrrole derivates.β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.An efficient and facile method for the synthesis of N-substituted pyrroles in moderate to good yields by the Paal-Knorr reaction of β-diketones with amines in the presence of β-cyclodextrin in aqueous media has been developed. Moreover, this process tolerated diamines （e.g., para-, metaor orthophenylenediamine） to construct bis-pyrrole or mono-pyrrole derivates.β-Cyclodextrin can be recovered easily after the reactions and reused without evident loss in activity.

关 键 词：Pyrrole Paal-Knorr β-Cyclodextrin Water 

分 类 号：O621.3[理学—有机化学]