Three new eudesmane sesquiterpenes from Artemisia vestita  

作　　者：Shuai-Hua Tian Xing-Yun Chai Ke Zan Ke-Wu Zeng Peng-Fei Tu 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center [2]Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine

出　　处：《Chinese Chemical Letters》2013年第9期797-800,共4页中国化学快报（英文版）

基　　金：financially supported by the grants from the National Natural Science Foundation of China(No.30973629);National Key Technology R&D Program‘‘New Drug Innovation’’of China(Nos.2012ZX09301002-002-002,2012ZX09304-005)

摘　　要：Three eudesmane sesquiterpene lactones, namely artemivestinolides A-C （1-3）, along with three known 11-epimeric lactones （4-6）, were isolated from the aerial parts ofArtemisia vestim. Their structures were elucidated on the basis of extensive spectroscopic analyses （IR, HR-ESIMS, 1D NMR and 2D NMR）, and the absolute configurations were determined by single-crystal X-ray diffraction （with copper radiation）. Furthermore, in an in vitro assay, the three new compounds exhibited a moderate inhibition of the lipopolysaccharide （LPS）-induced nitric： oxide （NO） production in BV-2 microglial cells.Three eudesmane sesquiterpene lactones, namely artemivestinolides A-C （1-3）, along with three known 11-epimeric lactones （4-6）, were isolated from the aerial parts ofArtemisia vestim. Their structures were elucidated on the basis of extensive spectroscopic analyses （IR, HR-ESIMS, 1D NMR and 2D NMR）, and the absolute configurations were determined by single-crystal X-ray diffraction （with copper radiation）. Furthermore, in an in vitro assay, the three new compounds exhibited a moderate inhibition of the lipopolysaccharide （LPS）-induced nitric： oxide （NO） production in BV-2 microglial cells.

关 键 词：Artemisia vestita Eudesmane sesquiterpene Artemivestinolide X-ray diffraction 

分 类 号：R284[医药卫生—中药学]