Antifungal variant bis(bibenzyl)s from the liverwort Asterella angusta  

作　　者：Jian-Bo Qu Ling-Mei Sun Hong-Xiang Lou 

机构地区：[1]School of Pharmaceutical Sciences Shandong University [2]Center for Drug Evaluation, SFDA

出　　处：《Chinese Chemical Letters》2013年第9期801-803,共3页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.30925038)

摘　　要：Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis（bibenzyl）s, riccardin I （1）, and angustatin A （2）. Their structures were established by spectroscopic analysis （1D NMR and 2D NMR, IR, MS）. Compound I is a novel variant riccardin-type bis（bibenzyl）, while compound 2 is the first nonheteratom-containing variant bis（bibenzyl） possessing a bibenzyl-phenanthrene skeleton.Bioassay-guided fractionation of the diethyl ether extract of the liverwort Asterella angusta led to the isolation of two antifungal bis（bibenzyl）s, riccardin I （1）, and angustatin A （2）. Their structures were established by spectroscopic analysis （1D NMR and 2D NMR, IR, MS）. Compound I is a novel variant riccardin-type bis（bibenzyl）, while compound 2 is the first nonheteratom-containing variant bis（bibenzyl） possessing a bibenzyl-phenanthrene skeleton.

关 键 词：Variant bis（bibenzyl）s Asterella angusta Antifungal activity 

分 类 号：TQ460.1[化学工程—制药化工] R284[医药卫生—中药学]