Three component reactions: An efficient and green synthesis of 3, 4-dihydropyrimidin-2-(1H)-ones and thiones using silica gel-supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate  

作　　者：Arash Ghorbani-Choghamarani Parisa Zamani 

机构地区：[1]Department of Chemistry, Faculty of Science, Ilam University

出　　处：《Chinese Chemical Letters》2013年第9期804-808,共5页中国化学快报（英文版）

基　　金：Financial support to this work by the Ilam University,Ilam,Iran is gratefully acknowledged

摘　　要：An environmentally benign aqueous protocol for the synthesis of 3,4-dihydropyrimidin-2-（ 1 H）-ones and thiones promoted by a green catalyst, silica gel-supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate, has been developed. The use of nontoxic, thermally stable and inexpensive amino acid catalyst makes the process simple with minimal amount of chemical waste. Compared with classical Biginelli reaction conditions, this new method has the advantages of high yields and simple workup procedures.An environmentally benign aqueous protocol for the synthesis of 3,4-dihydropyrimidin-2-（ 1 H）-ones and thiones promoted by a green catalyst, silica gel-supported L-pyrrolidine-2-carboxylic acid-4-hydrogen sulfate, has been developed. The use of nontoxic, thermally stable and inexpensive amino acid catalyst makes the process simple with minimal amount of chemical waste. Compared with classical Biginelli reaction conditions, this new method has the advantages of high yields and simple workup procedures.

关 键 词：3 4-Dihya ropyrimldin-2 -（ 1H）-ones（DHPMs）L-Pyrrolidine-2 -carboxylic acid-4-hydrogensulfateOne-potThree-component 

分 类 号：O626[理学—有机化学]