Transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides  

作　　者：Meng-Xue Wei Xiao-Hui Gao Tian-Cai Li Chun-An Fan Xue-Qiang Li 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University [2]School of Chemistry and Chemical Engineering, Ningxia University

出　　处：《Chinese Chemical Letters》2013年第9期837-839,共3页中国化学快报（英文版）

基　　金：NSFC(No.21062014);the‘‘211’’Project in Ningxia University for financial support

摘　　要：The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Interestingly, the product 2b has shown a promising anticancer activity against HeLa cell lines （IC50 = 0.19μmol/L）.The selective transalkylation of N-methyl tertiary amines with 3,4-dibromobutenolides is described. The N-methyl group of the parent tertiary amines was replaced by alkenyl units of the butenolides; and a series of butenolide-containing tertiary enamines were obtained in moderate to good yields. Interestingly, the product 2b has shown a promising anticancer activity against HeLa cell lines （IC50 = 0.19μmol/L）.

关 键 词：Amination Enamines Butenolides Tertiary amine Transalkylation 

分 类 号：O621.25[理学—有机化学]