A solid phase approach to PDMP analogs: A general strategy for combinatorial library  

作　　者：Chun-Hong Dong Yue-Teng Zhang Gang Huang Jing-Jing Dong Hong-Xu Liu Xian-Hai Tian Jing Wang Zhi-Gang Lv Li-Na Song Wen-Quan Yu 

机构地区：[1]College of Chemistry and Molecular Engineering, Zhengzhou University [2]Jiaozuo University

出　　处：《Chinese Chemical Letters》2013年第9期845-848,共4页中国化学快报（英文版）

摘　　要：The present work reports the first solid phase synthesis of biologically interesting D-threo-l-phenyl-2- decanoylamino-3-morpholino-l-propanol （D-threo-PDMP） derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate （5） in a relatively short sequence and the subsequent derivatization of 5, which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs （10 and 10＇）. With this method, a 5280-member compound library has been successfully built by IRORI Nanokan system.The present work reports the first solid phase synthesis of biologically interesting D-threo-l-phenyl-2- decanoylamino-3-morpholino-l-propanol （D-threo-PDMP） derivatives. This synthetic strategy includes facile preparation of versatile azido intermediate （5） in a relatively short sequence and the subsequent derivatization of 5, which led to a series of sulfonamide, urea and heterocycle substituted PDMP analogs （10 and 10＇）. With this method, a 5280-member compound library has been successfully built by IRORI Nanokan system.

关 键 词：Solid phase synthesis PDMP analogs Combinatorial library 

分 类 号：O621.25[理学—有机化学]