血管内皮生长因子与妊娠肝内胆汁淤积症相关性研究  

Analysis of vascular endothelial growth factor and its correlation with pregnancy intrahepatic cholestasis

作　　者：翟洪波[1] 孙文超[1] 

机构地区：[1]浙江杭州市第一人民医院产科,310006

出　　处：《中国优生与遗传杂志》2013年第9期61-62,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨血管内皮生长因子(VEGF)在妊娠期肝内胆汁淤积症(ICP)中的表达及其意义。方法选取2010年8月至2012年7月在杭州市第一人民医院剖宫产分娩的单胎妊娠ICP患者48例为研究组(轻度34例、重度14例),选择性剖宫产正常单胎妊娠45例为对照组。采用酶联免疫吸附试验法(ELISA)测定两组外周血清及其新生儿脐血VEGF的水平。结果①研究组(轻度)外周血清VEGF水平为167.25±56.78ng/L,研究组(重度)外周血清VEGF水平为103.48±60.68ng/L;对照组外周血清VEGF水平为245.71±68.02ng/L。研究组(轻度和重度)外周血清中VEGF水平显著低于对照组,差异有显著统计学意义;而研究组(重度)VEGF水平显著低于研究组(轻度)患者,差异有显著统计学差异。②研究组(轻度)脐血VEGF水平为418.42±142.11ng/L,研究组(重度)脐血VEGF水平为375.35±127.42ng/L;对照组脐血VEGF水平为467.22±138.23ng/L。研究组(轻度)患者脐血VEGF与对照组相比较,两组无明显差异;而研究组(重度)脐血VEGF水平显著低于研究组(轻度),差异有显著统计学意义。结论 ICP患者VEGF减少,出现胎盘血管内皮细胞受损,血管通透性下降。VEGF的异常表达可能与ICP发病存在一定的相关性。Objective： To investigate the vascular endothelial growth factor （VEGF） expression and its significance in intrahepatic cholestasis of pregnancy （ICP）. Methods： Single pregnancies patients in the First People＇s Hospital of Hangzhou single pregnancies from August 2010 to July 2012, 48 cases of cesarean delivery with ICP for the study group （ 34 cases with mild to severe 14 cases）, 45 cases of selective cesarean normal for the control group. Use enzyme -linked immunosorbent assay method （ELISA） for the determi- nation of the two groups with peripheral serum and umbilical levels of VEGF. Results： ① The peripheral serum VEGF levels of the study group （mild） was 167.25 ± 56.78ng/L, the study group （severe） 103.48 ± 60. 68ng/L; the control group peripheral serum VEGF was 245.71 ± 68.02ng/L. Research groups （mild and severe） peripheral serum VEGF levels significantly lower than those in the control group, the difference was statistically significant; study group （severe） VEGF levels were significantly lower than the study group patients （mild）, the difference was statistically significant differences. ②VEGF of umbilical blood in the research group （mild） was 418.42 ± 142. 11 ng / L, study group （severe） 375. 35 ± 127.42ng / L; VEGF of umbilical blood in the control group was 467. 22 ± 138. 23ng / L. Compared VEGF of umbilical blood in the control group with the study group （ mild）, no significant difference; VEGF of umbilical blood in the study group （severe） significantly lower than in the study group （ mild）, the difference was statistically significant. Conclusion： VEGF of ICP patients was reduced, placental vascular endothelial cell damaged, vascular permeability decreased. The abnormal expression of VEGF may be related to the pathogenesis of ICP.

关 键 词：血管内皮生长因子 妊娠期肝内胆汁淤积症 围产儿结局 

分 类 号：R714.2[医药卫生—妇产科学]