The simulation of multiphase flow field in implantable blood pump and analysis of hemolytic capability  

作　　者：李铁岩 叶亮 洪方文 刘登成 范慧敏 刘中民 

机构地区：[1]Department of Cardiac Surgery, Shanghai East Hospital Affiliated to Tongji University [2]China Ship Scientific Research Center

出　　处：《Journal of Hydrodynamics》2013年第4期606-615,共10页水动力学研究与进展B辑（英文版）

基　　金：Project supported by the National High Technology Research and Development Program of China (863 Program,Grant No. 2007AA02Z439);The Key Disciplines Group Construction Project of Pudong Health Bureau of Shanghai (Grant No. PKzxkq2010-01);the Outstanding Leaders Training Program of Pudong Health Bureau of Shanghai (Grant No.PKR2011-01)

摘　　要：The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and the shear stress distribution is obtained. A hemolytic prediction model based on the shear stress is built based on the calculation results, and it can be used for qua- ntitative predictions of the hemolytic behavior of a blood pump. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the pump NIVADIII is 5 L/min and the outflow tract pressure is 100 mmHg. According to the tests, the plasma free hemoglobin （FHB） content and the hematocrit （HCT） are measured after 0 s, 0.5 s, 1 s, 1.5 s 4 s. At the end of each experiment Normal Index of Hemolysis （NIH） of NIVADIII is calculated. The average of NIH is 0.0055 g/100L, almost identi- cal with that obtained from the hemolytic prediction model. This method can be applied in the selection stage of a blood pump.The numerical simulation of the axial flow impeller blood pump NIVADIII is carried out by using a CFD multiphase flow model. The hydrodynamic performance of the pump and the flow field in the pump are analyzed, and the shear stress distribution is obtained. A hemolytic prediction model based on the shear stress is built based on the calculation results, and it can be used for qua- ntitative predictions of the hemolytic behavior of a blood pump. Hemolysis tests in vitro were performed 6 times with fresh bovine blood. At each time, the flow of the pump NIVADIII is 5 L/min and the outflow tract pressure is 100 mmHg. According to the tests, the plasma free hemoglobin （FHB） content and the hematocrit （HCT） are measured after 0 s, 0.5 s, 1 s, 1.5 s 4 s. At the end of each experiment Normal Index of Hemolysis （NIH） of NIVADIII is calculated. The average of NIH is 0.0055 g/100L, almost identi- cal with that obtained from the hemolytic prediction model. This method can be applied in the selection stage of a blood pump.

关 键 词：blood pump multiphase flow numerical simulation HEMOLYTIC 

分 类 号：O359[理学—流体力学] R312[理学—力学]