高血压患者运动血压与高敏C-反应蛋白和脉搏波传导速度的相关性分析  

Correlation of exercise blood pressure with serum high-sensitivity C-reactive protein levels and brachial-ankle pulse wave velocity in patients with essential hypertension

作　　者：黄鹤飞[1] 陈爱民[1] 俞子东[1] 沈亚云[1] 

机构地区：[1]新昌县人民医院心内科,312500

出　　处：《浙江医学》2013年第15期1410-1412,1441,共4页Zhejiang Medical Journal

摘　　要：目的观察原发性高血压患者运动时血压水平与高敏C反应蛋白(hs-CRP)和踝臂脉搏波传导速度(BaPWV)的相关性。方法选择高血压病1、2级患者共80例,均行血脂、血糖、hs-CRP和BaPWV检测,然后所有受试者均接受运动平板试验,分别测量运动前、运动亚极量、运动后的血压情况,按照运动高血压的标准,将受试者分为运动高血压组(H组)和运动血压正常组(N组),比较两组间收缩压(SBP)、舒张压(DBP)、脉压(PP)、hs-CRP和BaPWV等指标,以及运动血压水平与hs-CRP、BaPWV的相关性。结果 H组hs-CRP浓度和BaPWV值[(8.42±3.82)mg/L、(19.84±8.13)m/s]均高于N组[(6.64±4.12)mg/L、(15.71±9.24)m/s](均P<0.05),并与运动亚极量时SBP、PP水平具有相关性(hs-CRP与SBP、PP,r=0.26、0.25,均P<0.05;BaPWV与SBP、PP,r=0.29、0.36,P<0.05或0.01)。结论运功高血压患者较运动血压正常者炎症反应和动脉硬化程度更明显,对运动高血压的早期发现和积极干预,可能在一定程度上能改善高血压患者的预后。Objective To investigate of the exercise blood pressure with serum high- sensitivity C- reactive protein （ hs- CRP ） levels and brachial- ankle pulse wave conduction velocity （ BaPWV ） in essential hypertension patients . Meth-ods Eighty patients with essential hypertension （level 1 and 2） were enrol ed in the study. Blood lipids, blood glucose（GLU）, hs- CRP were measured and BaPWV was detected. Treadmil exercise testing was performed and the blood pressure was measured before, during and after exercise. The patients were identified as exercise hypertension group （group H） and normal blood pressure group（group N） according to exercise blood pressure. The systolic blood pressure（SBP）, diastolic blood pres-sure （DBP）, pulse pressure （PP）, hs- CRP and BaPWV were compared between two groups; the correlation of exercise blood pressure level with hs- CRP, BaPWV was analyzed. Results The hs- CRP level and BaPWV value of group H were significantly higher than those of group N （hs- CRP 8.42±3.82 vs 6.64±4.12mg/L, P〈0.05;BaPWV 19.84±8.13 vs 15.71±9.24m/s, P〈0.05）. hs- CRP level was correlated with SBP and PP values （r=0.25 and 0.26, P〈0.05）, BaPWV was correlated with SBP and PP values （r=0.29 and 0.36, P〈0.05 or 0.01）. Conclusion Patients with exercise hypertension have more severe inflammatory response and arteriosclerosis than patients with normal exercise blood pressure.

关 键 词：运动高血压 高敏C反应蛋白 踝臂脉搏波传导速度 运动平板试验 

分 类 号：R544.1[医药卫生—心血管疾病]