高位胸段硬膜外阻滞治疗顽固性心绞痛及其对循环内皮细胞的影响  

The role of thoracic epidural anesthesia on patient with refractory angina pectoris and the change of circulation endothelium cell level

作　　者：陈国忠[1] 孙淑清[1] 李中言[1] 任旷[1] 李学[1] 王化民[2] 曲仁海 

机构地区：[1]吉林军医学院附属医院麻醉科,吉林省吉林市132013 [2]哈尔滨医科大学第一临床医学院

出　　处：《临床心血管病杂志》2000年第10期455-456,共2页Journal of Clinical Cardiology

摘　　要：目的 :观察高位胸段硬膜外阻滞 ( TEA)对顽固性心绞痛 ( FAP)的治疗效果及循环内皮细胞 ( CEC)数量。方法 :2 0例 FAP患者接受 TEA治疗 ,观察疗效和心电图变化 ,并于 TEA治疗前及治疗结束时检测血浆 CEC的变化。结果 :TEA治疗后心绞痛缓解率 10 0 % ,心电图 ST段压低导联数和 ST压低值显著减少 ( P <0 .0 5 ) ,CEC显著减少 ( P <0 .0 1)。结论 :TEA治疗 FAP疗效满意 。Objective:To investigate the role of thoracic epidural anesthesia (TEA) on patient with refractory angina pertoris and the change of the number of circulation endothelium cell level.Method:Twenty patients with refractory angina pertoris were treated with TEA.The clinical effect of thoracic epidural anesthesia on angina pectoris was recorded and the number of circulation endothelium cell was counted before and after TEA respectively.Result:The effective rate of patients′ chest pain relief was 100% after TEA.The sites of ST depression and total ST depression of ECG decreased significantly after TEA (P< 0.05 ).Meanwhile,the number of circulation endothelium cell reduced significantly (P< 0.01 ).Conclusion:TEA may be used as a new promising therapeutic approach for patients with refractory angina pectoris and may be associated with protective effect on circulation endothelium cell.

关 键 词：硬膜外阻滞 心绞痛 循环内皮细胞 

分 类 号：R541.405[医药卫生—心血管疾病]