电感耦合等离子体质谱法测定低硼硅玻璃安瓿中锑的浸出量  

ICP-MS determination of metallic element antimony content in low borosilicate glass ampoule

作　　者：吕斌[1] 李云[1] 郑子栋[1] 郭毅[1] 

机构地区：[1]河南省食品药品检验所化学室,河南郑州450003

出　　处：《中国现代医药杂志》2013年第9期50-52,共3页Modern Medicine Journal of China

摘　　要：目的建立电感耦合等离子体质谱法测定低硼硅玻璃安瓿中锑浸出量的方法。方法用4％的乙酸溶液浸出安瓿中的锑，用电感耦合等离子体质谱法（ICP—MS）测定，研究ICP—MS测定锑的光谱干扰，建立干扰方程来消除光谱干扰。结果锑在0～17．82μg／L的范围线性关系良好（r=0．99993），加样回收率98．3％，RSD=2．6％（n=6），检出限为0．027μg／L。结论所建立的检测方法专属性强、简便、灵敏度高，可用于玻璃安瓿中锑浸出量的测定，有效控制低硼硅玻璃安瓿中锑的残留量。Objective To establish a determination method for the determination of metallic element antimony content in low borosilicate glass ampoule. Methods With 4% acetic acid solution leaching ampoule of Sb, using inductively coupled plasma mass spectrometry （ICP-MS）, studied the ICP-MS determination of antimony spectrum interference. Results The lin- ear concemtration range of antimony was 0-17.82μg/L, and was good linear relationship （r=0.99993） ; the recovery rate was 98. 3%, RSD=2.6%（n=6）, the limit of detection was 0.027μg/L. Conclusion The established method is special, easy, accurate and sensitive, it can be used for determination of antimony in glass ampoule leaching amount, effectively control the residues of antimony in low borosilicate glass ampoule.

关 键 词：电感耦合等离子体质谱法 低硼硅玻璃安瓿 锑 测定方法 

分 类 号：R472[医药卫生—护理学]