酮康唑经糖尿病及正常大鼠皮肤的体外透过性差异比较  

Difference comparison of percutaneous extracorporal permeability of ketoconazole in diabetic and normal rats

作　　者：陈伟光 苏碧雅[2] 李国锋[3] 房振春 庄志铨[4] 

机构地区：[1]广东省佛山市顺德聚龙医院,广东佛山528319 [2]甘肃省天水市第一人民医院,甘肃天水741000 [3]南方医科大学南方医院,广州510515 [4]广东药学院附属第一医院药学部,广州510080

出　　处：《中国当代医药》2013年第27期7-9,共3页China Modern Medicine

基　　金：广东省医学科研基金(A2011323)

摘　　要：目的比较酮康唑经糖尿病和正常大鼠皮肤体外透过性的差异。方法利用扩散池(Franzcells)技术对临床常用的抗真菌药物酮康唑进行研究,将其制成凝胶剂、乳膏剂和软膏剂,比较其经糖尿病和正常大鼠皮肤的渗透吸收差异。结果酮康唑乳膏经糖尿病皮肤透过速率大于正常组,且糖尿病模型组与正常组之间差异有统计学意义(P<0.05)。结论透过性差异的产生与糖尿病状态下皮肤自身的改变有关。Objective To compare the difference of percutaneous extracorporal permeability of ketoconazole in diabetic and normal rats. Methods The diffusion cell （Franzcells） technique was used to study the commonly used antifungal drug ketoconazole and make them into gels, cream and ointment; the difference of percutaneous permeability in dia- betic and normal rats was analyzed. Results The percutaneous permeable rate of ketoconazole cream in diabetic rats was larger than that in normal rats, the difference was significant （1~〈0.05）. Conclusion The occurrence of permeability difference is related to the skin changes under diabetic conditions.

关 键 词：酮康唑 糖尿病 皮肤体外透过性 

分 类 号：R587.1[医药卫生—内分泌]