细胞辅助自体脂肪移植术治疗先天性乳房发育不良的临床观察  

Clinical observation of cell-assisted autologous lipotransfer in the treatment of congenital breast dysplasia

作　　者：崔舜瑀 

机构地区：[1]吉林省肿瘤医院乳腺外一科,长春130021

出　　处：《中国当代医药》2013年第27期168-169,共2页China Modern Medicine

摘　　要：目的探讨细胞辅助自体脂肪移植术治疗先天性乳房发育不良的临床效果。方法选取本院2009年10月～2012年10月收治的42例84侧先天性乳房发育不良患者,在对其进行肿胀麻醉的前提下,使用容积为50 ml的注射器利用负压方式抽吸患者身体赘积部位的脂肪,然后利用生理盐水对获取的脂肪颗粒进行冲洗,对抽取的脂肪进行静置,之后过滤其中的液体和油状物,通过700 r/min进行3 min的离心运动,清除上清。对一半脂肪粒进行血管基质层细胞(SVFs)提取,然后和另一半脂肪粒进行混合,之后对患者的乳房后间隙和皮下进行注射,单侧乳房每次注射量控制在100～150 ml,相邻两次注射的间隔时间控制在3～6个月。观察患者的治疗满意度及术后并发症情况。结果经过治疗,42例84侧先天性乳房发育不良患者中12例24侧填充1次,24例48侧填充2次,6例12侧患者填充3次,患者对治疗结果的总满意度为95.2%;术后患者未出现纤维囊形成、脂肪液化、微钙化、硬结等并发症,且治疗未对患者的泌乳功能产生影响。结论对先天性乳房发育不良患者行细胞辅助自体脂肪移植术治疗效果显著,值得推广和应用。Objective To investigate the clinical effect of cell-assisted autologous lipotransfer in the treatment of con- genital breast dysplasia.Methods 42 cases of patients with 84 sides of congenital breast dysplasia were selected from our hospital from October 2009 to October 2012.On the premise of tumescent anesthesia on it,accumulated fat was as- pirated by negative pressure suction with 50 ml syringe,and then the fat particles were douched by physiological saline.The liquid and oil in fat was filtrated out after still standing,and supernatant was cleared away by eccentric ex- ercise with 700 r/min for three minutes.SVFs extraction was conducted on half of the fat particles,and then they were mixed with the other half of fat granules.Retromammary cellular space and subcutaneous injection was given to the patients.The dose of drug per administration for unilateral breast should be controlled in the range of 100 to 150 ml, and interval time of two adjacent injections should be controlled in 3 to 6 months.The treatment satisfaction and post- operative complications of patients were observed.Results After the treatment on 42 cases of patients with 84 sides of congenital breast dysplasia,filling once in 12 cases with 24 sides,filling for 2 times in 24 cases with 48 sides,filling for 3 times in 6 cases with 12 sides.Patients total satisfaction on treatment outcomes was 95.2%.After operation,no patient appeared fibrous capsule formation,fat liquefaction,microcalcification,induration and other complications.And treatment did not affect lactation function of patients.Conclusion Cell-assisted autologous lipotransfer has a remarkable curative effect in the treatment of congenital breast dysplasia,so it is worthy of promotion and application.

关 键 词：先天性乳房发育不良 填充 细胞辅助自体脂肪移植术 

分 类 号：R655.8[医药卫生—外科学]