苦山柰化学成分的研究  

STUDIES ON THE CHEMICAL CONSTITUENTS OF KAEMPFERIA MARGINATA

作　　者：余竞光[1] 余冬蕾[1] 章菽[2] 罗秀珍[1] 孙兰[1] 郑才成 陈毓亨[2] 

机构地区：[1]中国医学科学院,中国协和医科大学药用植物研究所,北京100094 [2]中国医学科学院,中国协和医科大学药物研究所,北京100050

出　　处：《药学学报》2000年第10期760-763,共4页Acta Pharmaceutica Sinica

基　　金：国家中医药管理局85攻关项目

摘　　要：目的　研究中药山柰的混杂品种苦山柰KaempferiamarginataCarey的化学成分。 方法　利用色谱技术进行分离纯化 ,根据化合物的理化性质和光谱数据进行结构鉴定。结果　从苦山柰的根茎分得苦山柰萜醇 (1)、8(14) ,15 sanderacopimaradiene 1α ,9α diol (2 )、8(14) ,15 sanderacopimaradiene 1α ,6 β ,9α triol (3)、吉马酮 (4 )、对 甲氧基 肉桂酸乙酯 (5 )和正 十五烷 (6 )。结论　苦山柰萜醇 (1)为新二萜醇 ,化学结构为 8(14) ,15 isopimaradiene 6α ol。2 ,3和 4是首次从该植物中分得。AIM To study the chemiacal constituents of the rhizomes of Kaempferia galanga L. (Zingiberaceae). METHODS Various chromatographic techniques were used to separate and purify. Their physico-chemical properties and spectral data were used to elucidate the structures. RESULTS Six compounds were isolated from the hexane extract of K.galanga . Their structures were identified as marginatol (1), 8(14),15-sanderacopimaradiene-1α,9α-diol (2), 8(14),15-sanderacopimaradiene-1α,6β,9α-triol (3), germacrone (4), trans -ethyl p -methoxycinnamate (5) and n -pentadecane (6) on the basis of spectral data (IR, MS, 1H- 1H , 13 C- 1H NMR, NOEs and HMBC). CONCLUSION Marginatol (1) is a new isopimarene diterpenoid and was elucidated as 8(14),15-isopimaradiene-6α-ol. Compounds 2, 3 and 4 were isolated for the first time from this plant.

关 键 词：苦山柰 姜科 二萜醇 苦山柰萜醇 化学成分 

分 类 号：R284.2[医药卫生—中药学] Q949.718.3[医药卫生—中医学]