吸烟对类风湿关节炎患者凝血与纤溶障碍的影响  

Effects of Smoking on Blood Coagulation and Fibrinolysis Impediment of Patients with Rheumatoid Arthritis

作　　者：武伟[1] 张延[1] 李文宁[1] 黄艳艳[1] 

机构地区：[1]海南省人民医院,海南海口570311

出　　处：《风湿病与关节炎》2013年第9期11-14,共4页Rheumatism and Arthritis

摘　　要：目的:观察吸烟对类风湿关节炎患者的凝血与纤溶障碍的影响。方法:将123例类风湿关节炎患者分为吸烟组66例和非吸烟组57例,进行治疗前后的凝血与纤溶的研究,并设健康对照组50例。结果:两组类风湿关节炎患者治疗前与健康组比较,有不同程度的凝血与纤溶障碍(P<0.05)。治疗前吸烟组患者与非吸烟组比较,有明显的凝血与纤溶障碍(P<0.05)。经治疗非吸烟组比吸烟组症状好转(有效率88.2%),且凝血与纤溶障碍有明显改善,两组比较,差异有统计学意义(P<0.01)。结论:吸烟可加重类风湿关节炎患者凝血与纤溶障碍,对该病的治疗和预后有不良影响。Objective：To observe the effects of smoking on blood coagulation and fibrinolysis impediment of patients with rheumatoid arthritis （ RA ） .Methods： 123 cases with RA were divided into the smoking group （ 66 cases ） and the non-smoking group （ 57 cases ） ,studying their blood coagulation and fibrinolysis impediment before and after treatment and comparing them with the healthy control group （ 50 cases ） .Results：The two treated groups had blood coagulation and fibrinolysis impediment of different levels before treatment （ P 〈 0.05 ） ,of which the smoking group was obvious than the non-smoking group （ P 〈 0.05 ） After treatment,the non-smoking group was better than the smoking group,with effective rate 88.2% and improvement of blood coagulation and fibrinolysis impediment.The difference of the two groups was statistically significant （P 〈 0.01 ） .Conclusion：Smoking was a cause to aggravate blood coagulation and fibrinolysis impediment of rheumatoid arthritis,had bad effects on its treatment and prognosis

关 键 词：关节炎 类风湿 凝血与纤溶障碍 吸烟 

分 类 号：R593.22[医药卫生—内科学]