缬沙坦和阿托伐他汀治疗对糖尿病大鼠心室重构的影响及机制  

Effect and mechanism of valsartan and atorvastatin to the ventricular remodeling of diabetic rat

作　　者：钱露[1] 施辉[2] 薛佳[3] 

机构地区：[1]西安交通大学内科 [2]南通大学第一附属医院肾内科 [3]江苏省人民医院老年病科

出　　处：《陕西医学杂志》2013年第9期1114-1118,共5页Shaanxi Medical Journal

摘　　要：目的:探讨糖尿病心肌病心室重构作用机制以及缬沙坦、阿托伐他汀治疗对糖尿病心肌心室重构影响。方法:STZ建立糖尿病大鼠模型,随机分为:糖尿病心肌病(DC)组、缬沙坦(Val)组、阿托伐他汀(Ato)组、联用(V+A)组、正常(CN)组。干预12周,测定血流动力学参数、心脏质量(BW)、左心室质量(LVW)、检测心肌组织中MMP2基因表达以及MMP2蛋白含量及活性。结果:与DM组相比,三个治疗组血流动力学指标及心室肥厚指标明显改善(P<0.05),MMP2mRNA有明显减少(P<0.05),MMP2蛋白含量及活性显著降低(P<0.5),而且两种药物联合治疗对上述指标改善更加显著。结论:缬沙坦和阿托伐他汀均可缓解糖尿病心肌病心室重构,其联合应用有协同治疗效果。其机制能与基质金属蛋白酶2的表达和活性调节有关。Objective：To investigate valsartan and atorvastatincalcium treatment on diabetic myocardial in-terstitial fibrosis effect and possible mechanism .,to provide theoretical basis for clinical medication .Methods ：To diabetic rats as the research object ,which were randomly divided into ：diabetes mellitus （DM ） group ,valsartan （Val） group ,atorvastatin （Ato） group ,combination （V ＋ A）group and normal（CN） group .Intervention in 12 weeks ,the determination of hemodynamic parameters ,ventricular hypertrophy index ,detection of MMP2 gene ex-pression and protein activity in myocardial tissue .Results ：Compared with DM group ,three hemodynamic index and ventricular hypertrophy index in treatment group reduced significantly （P 〈 0 .05） ,MMP2 mRNA was signifi-cantly descended （P 〈 0 .05） ,MMP2 protein activity reduced significantly （P 〈 0 .5） ,and two drugs combination of the above indicators to improve even more significant .Conclusion：Valsartan and Atorvastatin therapy candescend the myocardial tissue in diabetic cardiomyopathy in MMP 2 gene expression and protein activity ,its joint application has significant treatment effect .

关 键 词：糖尿病 并发症 心肌疾病 药物疗法 心室复建 受体 血管紧张素 拮抗剂和抑 制剂 模型 动物 大鼠 @阿托伐他汀 @缬沙坦 

分 类 号：R587.1[医药卫生—内分泌]