口服疫苗的研究进展  

Progress in research of oral vaccines

作　　者：曾春桂[1] 吴浩飞[2] 黄仕和[2] 

机构地区：[1]黄冈市中医医院,湖北黄冈438000 [2]武汉生物制品研究所有限责任公司,湖北武汉430207

出　　处：《中国热带医学》2013年第8期1031-1034,共4页China Tropical Medicine

摘　　要：在发达国家和发展中国家,接种疫苗是预防疾病的一个重要的方式。目前全球需要更有效,可接受的,符合成本效益的和可靠的免疫方法来预防许多致命性疾病。通过人用口服疫苗将有助于提供一种有效的疫苗接种策略,特别是在发展中国家。对于大多数的病原体感染黏膜,用于产生粘膜免疫的口服疫苗可以作为强大的第一道防线。阐明口服疫苗作用机制将有助于设计更有效的新一代疫苗。本文阐述了目前获得批准生产的预防5种疾病的口服疫苗。同时,利用转基因植物生产疫苗是近年来生物技术领域发展的热点,具有一定的优势和良好的前景。Vaccination is an important tool for handling healthcare programs both in developed and developing countries. The current global calls for a more-efficacious, acceptable, cost-effective and reliable method of immunization for many fatal diseases. It is hoped that the adoption of oral vaccines for human will help to provide an effective vaccination strategy, especially in developing countries. Mucosal immunity generated by oral vaccines can serve as a strong first line of defense against most of the pathogens infecting through the mucosal lining. Advances in elucidating the mechanism of action of oral vaccines will facilitate the design of more effective, new generation vaccines. In this review, we describe the current five licensed vaccines against important childhood diseases. Meanwhile, vaccine produced by transgenic plants is the hot topic of recent development of biotechnology ,It has certain advantages and promising prospects.

关 键 词：口服 疫苗 研究 进展 

分 类 号：R186[医药卫生—流行病学]