腹部开放性损伤犬经海水浸泡后血液动力学及病理学的变化  

Hemodynamic and pathologic changes in open abdominal wound after seawater immersion in dog

作　　者：王育红[1] 鹿尔驯[1] 虞积耀[1] 李辉[1] 王大鹏[1] 周正谋[1] 

机构地区：[1]海军总医院普外科,北京100037

出　　处：《中华外科杂志》2000年第9期700-702,I038,共3页Chinese Journal of Surgery

基　　金：解放军总后卫生部"九五"课题项目!(96 -L0 0 4)

摘　　要：目的　犬腹部开放性损伤经海水浸泡后机体血液动力学及主要脏器病理组织学变化。　方法　以成年杂种犬为实验动物。犬随机分为单纯腹部开放性损伤组 (10只 )和腹部伤加海水浸泡组 (12只 )。观察腹部开放性损伤后经海水浸泡不同时间及实验动物打捞出水后平均动脉压、肺动脉嵌压、中心静脉压、心输出量、心指数及心、肺、肝、肾、肠、胃在光、电镜下的病理组织学变化。　结果　与单纯腹部开放性损伤组相比 ,腹部开放性损伤经海水浸泡后可导致严重的血液动力学紊乱 ,且伤情更为严重 (P <0 0 1)。致伤动物打捞出水后平均存活时间为 3 2h ,病死率达 10 0 % ,远高于单纯腹部开放性损伤组。　结论　腹部开放性损伤犬经海水浸泡后血液动力学、病理组织学方面变化与单纯腹部开放性损伤犬明显不同 ,其机体的损伤程度更为严重 ,因此 。Objective[WT5”BZ] To study the experimental basis for the treatment to the sick and wounded with abdominal open wound in land warfare and naval battle. [WT5”HZ]Methods[WT5”BZ] Animal model was made with adult dogs to observe the changes of mean artery pressure (MAP), pulmonary capillary wedge pressure (PCWP), central vein pressure (CVP), cardiac output (CO), cardiac index (CI) and pathologic changes of heart, pulmonary, hepatic, nephritic, intestinal, and gastric tissues under the optical and electrical microscope. [WT5”HZ]Results[WT5”BZ] Comparing with simple open abdominal, the hemodynamic disorder in open wound after seawater immersion was more serious; with a higher death rate. [WT5”HZ]Conclusions[WT5”BZ] There was differences in hemodynamic and pathologic changes in seawater immersion wound and general wound. The body damaged is seriously when open abdominal wound immersed in seawater. Special measure must be taken in treating open abdominal wound after seawater immersion. [WT5”HZ]

关 键 词：腹部开放性损伤 血液动力学 海水浸泡 病理学 

分 类 号：R656[医药卫生—外科学]